Single injection of 89Zr labeled KN035 in subjects to observe KN035 affinity in PD-L1 expressed Solid tumors by using PET imaging.

89Zr-KN035

Hua Zhang

Yicong Bian

Liyan Miao, PhD

Jianan Huang, PhD

This is a single arm study by using 89Zr-labeled KN035 (89Zr-KN035) PET imaging to evaluate the biodistribution and target lesion uptake of 89Zr-KN035 in patients with PD-L1 positive advanced solid tumors.

The overall purpose of the study is to evaluate the biodistribution and target lesion uptake of 89Zr-KN035 in patients with PD-L1 positive advanced solid tumors by using PET imaging. Safety will be observed after 89Zr-KN035 injection, and radiation dosimetry of 89Zr-KN035 will be calculated.

89Zr-KN035 PET Imaging in Patients With Advanced Solid Tumors

89Zr-labeled KN035 PET Imaging in Patients With PD-L1positive Advanced Solid Tumors

Blood samples will be collected and assessed by timepoints.

All adverse events will be assessed by CTCAE v 4.03 and evaluated if treatment-related or not.

Laboratory tests (blood, urine) will be conducted by time. Significant changes will be assessed by CTCAE v 4.03.

Vital signs (heart rate, respiratory rate, blood pressures and body temperature) data will be collected by time. Significant changes will be assessed by CTCAE v4.03.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
89Zr-KN035 PET Imaging in Patients With Advanced Solid Tumors	NCT03638804	Solid Tumor, Ad...	89Zr-KN035	18 Years - 75 Years	The First Affiliated Hospital of Soochow University
89Zr-KN035 PET Imaging in Patients With Advanced Solid Tumors	NCT03638804	Solid Tumor, Ad...	89Zr-KN035	18 Years - 75 Years	The First Affiliated Hospital of Soochow University
89Zr-KN035 PET Imaging in Patients With Advanced Solid Tumors	NCT03638804	Solid Tumor, Ad...	89Zr-KN035	18 Years - 75 Years	The First Affiliated Hospital of Soochow University
89Zr-KN035 PET Imaging in Patients With Advanced Solid Tumors	NCT03638804	Solid Tumor, Ad...	89Zr-KN035	18 Years - 75 Years	The First Affiliated Hospital of Soochow University

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Spots Global Cancer Trial Database for 89zr

Every month we try and update this database with for 89zr cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for 89zr cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.