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Female Urogenital Diseases and Pregnancy Complications

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12 women with Polycystic Ovary Syndrome (PCOS) as defined by NIH criteria

12 with an android pattern as defined by a waist-to-hip greater than 0.85

12 will have a gynoid pattern as defined by a waist-to-hip ratio less than 0.78

Adeline Divoux, PhD

Steven R Smith, MD

The purpose of this study is to collect data to help understand why some women develop Polycystic Ovary Syndrome (PCOS) associated with decreased lower-body fat.

Epigenetics may represent a new regulator mechanism explaining gluteal vs. abdominal fat differences.

Adipose Tissue and Polycystic Ovary Syndrome (PCOS)(EIFFEL)

Adipose Tissue Angiogenesis in Polycystic Ovary Syndrome (PCOS)

Resting Metabolic Rate (RMR) will measure the resting metabolic rate/respiratory quotient (RMR/RQ) and substrate utilization.

Energy expenditure and respiratory quotient standardized for temperature, pressure, and moisture will be calculated at one-minute intervals, over 30 minutes.

The angiogenesis capacity of each adipose tissue depot will be determine by an in vitro angiogenesis test.

Measurement will be obtained with Fluorescence-activated cell sorting (FACS).

Identify different and similar biomarkers in obese and PCOS women, from abdominal and gluteal adipose tissue samples. Total RNA, micro RNA and DNA will be extracted from each type of cells using FACS-cell sorting analysis.

Adipose tissue oxygen content will be measured using the Licox CMP microprocessor.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Adipose Tissue and Polycystic Ovary Syndrome (PCOS)(EIFFEL)	NCT01745471	Polycystic Ovar... Metabolic Disea... Overweight		20 Years - 40 Years	AdventHealth Translational Research Institute
Adipose Tissue and Polycystic Ovary Syndrome (PCOS)(EIFFEL)	NCT01745471	Polycystic Ovar... Metabolic Disea... Overweight		20 Years - 40 Years	AdventHealth Translational Research Institute

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