Neoplasms

All Conditions

Rare Diseases

Carcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Acute Graft Versus Host Disease

The patients will undergo four IRT fractions in one week

Interventional Radiotherapy

VALENTINA LANCELLOTTA

To evaluate the degree of acute and long-term intestinal, urinary and vaginal toxicity, and the impact on sexual activity of an accelerated fractionation of high dose rate interventional radiotherapy (IRT-HDR) in patients with locally advanced cervical cancer (IB2 - VA, N+/-).

Observational, monocentric and prospective study. All patients with locally advanced cervix cancer will be underwent to radiochemotherapy followed by accelerated interventional radiotherapy (brachytherapy). Fist endpoints wer severe acute and late gastrointestinal, and urinary toxicities and sexual activity.

Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy

EROS 3 Study Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy Brachytherapy in Terms of Overall Toxicity and Sexual Activity

Acute and late toxicities will evaluated with CTCAE scale to analyze the safety of accelerated interventional radiotherapy

Acute and late urinary toxicities will evaluated with CTCAE scale to analyze the safety of accelerated interventional radiotherapy

Sexual activity will evaluated with CTCAE scale to analyze the safety of accelerated interventional radiotherapy

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy	NCT06398938	Locally Advance...	Interventional ...	18 Years -	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy	NCT06398938	Locally Advance...	Interventional ...	18 Years -	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy	NCT06398938	Locally Advance...	Interventional ...	18 Years -	Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Spots Global Cancer Trial Database for acute and late toxicities