Neoplasms

Blood and Lymph Conditions

Immune System Diseases

All Conditions

Infections

Rare Diseases

Lymphoma

Virus Diseases

Lymphoma, Extranodal NK-T-Cell

Lymphoma, T-Cell

Lymphoma, Non-Hodgkin

Neoplasms by Histologic Type

Lymphosarcoma

Chidamide is given 30mg,5mg/pill,twice a week, for at least 6 weeks

Chidamide is given 10mg,5mg/pill, everyday,for at least 6 weeks.

Chidamide BIW

Chidamide QD

Huiqiang Huang, Professor

1. To compare the therapeutic effects, safety and the corresponding pharmacokinetics and pharmacodynamics between two different method of drug administration: 10mg, daily and 30mg/d, twice every week, and find out the more effect way of Chidamide administration.
2. To examine whether Chidamide could activate EB virus, and whether the above two different ways of administration are different in EB virus activation.

Currently, Chidamide is taken twice a week, this comes from cell experiment and phase I clinical trial, which showed that the de-acetylation effect of Chidamide could last for 72 hours after administration. However, daily administration of Chidamide may create a more steady Chidamide concentration, thus improve the de-acetylation effect of Chidamide, so it's necessary to compare the two different ways of administration.

Current study showed that Romidepsin, a HDACI, could activate EBV during the treatment of NKTCL, whether Chidamide, as a novel HDACI, could activate EBV is still not clear, so this problem is worth to be accessed.

Differences Between Chidamide Taken Daily and Twice a Week in Therapeutic Effect，Pharmacokinetics, Pharmacodynamics and EB Virus Activation

Research About the Differences Between Chidamide Taken Daily and Twice a Week in Pharmacokinetics

The data of the trial would be accessable on the corresponding website after the trial is finished.

Huiqiang Huang

Doctor

Spots Global Cancer Trial Database for administration method