Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Rare Diseases

Melanoma

Neuroendocrine Tumors

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Neoplasms, Nerve Tissue

Nevus, Pigmented

Nevus

Nevi and Melanomas

Skin Neoplasms

Skin Diseases

Neuroendocrine Tumor

Neuroepithelioma

5mm skin metastasis or primary melanoma biopsy

Skin biopsy

Stéphane DALLE, MD, Prof.

This is an interventional mono-centric study in patients with BRAF mutated metastatic melanoma treated with BRAF/MEK inhibitors. The aim of the study is to test the grafting of patient tumoral cells in avian embryo and develop a predictive in vivo model for patient treatment response.

Interest of Tumor Replicates in Avian Embryo to Model Therapeutic Effects of BRAFi/MEKi in BRAF Mutated Melanoma

Interest of Tumor Replicates in Avian Embryo to Model Therapeutic Effects of BRAF Inhibitors/MEK Inhibitors (BRAFi/MEKi) in BRAF Mutated Melanoma

Number of grafted embryo which develop tumor measurable by 3D microscopy

Survival rate in avian embryo after treatment injections in different concentrations

weight of avian embryo after treatment injections in different concentrations

Height of avian embryo after treatment injections in different concentrations

Presence of cardiac malformation in avian embryo after treatment injections in different concentrations

Presence of craniofacial malformation in avian embryo after treatment injections in different concentrations

Embryo tumor volume obtained by confocal microscopy before treatment administration compared with tumor volume of non-treated embryo

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Interest of Tumor Replicates in Avian Embryo to Model Therapeutic Effects of BRAFi/MEKi in BRAF Mutated Melanoma	NCT04039672	Melanoma	Skin biopsy	18 Years -	Hospices Civils de Lyon
Interest of Tumor Replicates in Avian Embryo to Model Therapeutic Effects of BRAFi/MEKi in BRAF Mutated Melanoma	NCT04039672	Melanoma	Skin biopsy	18 Years -	Hospices Civils de Lyon

Spots Global Cancer Trial Database for avian embryo

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