Neoplasms

All Conditions

Carcinoma

Carcinoma, Basal Cell

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neoplasms, Basal Cell

Patients with histologically proven basal cell carcinoma who were candidates for treatment with ALA-PDT

treatment of bcc with 5_ALA cream 20% topical administration once monthly+ photodynamic therapy (red light) 120 j/cm2 once monthly

photodynamic therapy

Zohreh Tehranchi-nia, assist.prof.

The purpose of this study is to evaluate the efficacy of photodynamic therapy in treatment of Basal cell carcinoma (BCC) and factors that affect response rate.

Background and Aim: Basal cell carcinoma (BCC) is the most common skin cancer .Photodynamic therapy _as a novel , non-invasive therapeutic approach _may be considered a valuable strategy. This study was designed with the aim of the evaluation of efficacy of PDT in treatment of BCC and factors that may affect response rate.

Materials and Methods: This was a clinical trial which was done on 28 BCCs. Patients were treated with ALA-PDT monthly for 1-6 sessions and evaluated for clinical response,cosmetic results and probable side effects.

Short Term Effects of Photodynamic Therapy in Basal Cell Carcinoma

Shahid Beheshti University of Medical Sciences

Zohreh Tehranchi-nia

The purpose of this study is to evaluate the efficacy of pdt in treatment of bcc and factors that affect response rate.

Evaluation of Efficacy of Photodynamic Therapy in Basal Cell Carcinoma

excellent: no scarring, atrophy, or induration, slight or no redness or change in pigmentation compared to the adjacent skin; good: no scarring, atrophy, or induration, moderate redness or increase in pigmentation compared to the adjacent skin; moderate: slight to moderate scarring, atrophy, or induration; and poor: extensive scarring, atrophy, or induration

superficial BCC (sBCC); pigmented BCC(pBCC);nodular BCC (nBCC)

past medical history of radiotherapy to the site of tumor before its appearance(for another reason)

categorized in 3 groups: complete response: there was no visible or palpable lesion; partial response: there was a visible or palpable lesion but the diameter of the lesion had reduced; no response: there was a visible or palpable lesion and the diameter of the lesion had not reduced

disappearance of the lesion in histologic examination

Patients with histologically proven basal cell carcinoma who would receive ALA-PDT for their lesion(s)

Aminolevulinic Acid-Photodynamic Therapy (ALA-PDT)

Age Continuous

Sex: Female, Male

Zohreh Tehranchi-nia, assist. prof

complete response

partial response

no response

Patients with histologically proven basal cell carcinoma who were candidates for photodynamic therapy

Clinical Response to Photodynamic Therapy

complete resolution in histologic examination

not complete resolution in histologic examination

from those 9 lesions with clinically complete reponse , 3 lesions were biopsied and assessed histologically.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Short Term Effects of Photodynamic Therapy in Basal Cell Carcinoma	NCT01015898	Basal Cell Carc...	photodynamic th...	18 Years -	Shahid Beheshti University of Medical Sciences
Evaluation of Efficacy of Photodynamic Therapy in Basal Cell Carcinoma	NCT00985829	Basal Cell Carc...	photodynamic th...	18 Years -	Shahid Beheshti University of Medical Sciences
Evaluation of Efficacy of Photodynamic Therapy in Basal Cell Carcinoma	NCT00985829	Basal Cell Carc...	photodynamic th...	18 Years -	Shahid Beheshti University of Medical Sciences
Evaluation of Efficacy of Photodynamic Therapy in Basal Cell Carcinoma	NCT00985829	Basal Cell Carc...	photodynamic th...	18 Years -	Shahid Beheshti University of Medical Sciences

Spots Global Cancer Trial Database for basal cell epithelioma