Neoplasms

All Conditions

Diseases and Abnormalities at or Before Birth

Skin and Connective Tissue Diseases

Hemangioma, Capillary

Port-Wine Stain

Hemangioma

Congenital Abnormalities

Skin Abnormalities

Skin Diseases

Neoplasms, Vascular Tissue

Neoplasms by Histologic Type

Antineoplastic Agents

All Drugs and Chemicals

Angiogenesis Inhibitors

Growth Inhibitors

Topical Antiangiogenic

Pulsed Dye Laser

John S Nelson, M.D,PhD

The researcher want to improve port wine stain (PWS) therapeutic outcome in response to laser therapy. The researcher want to determine whether the combined use of pulsed dye laser (PDL) therapy and topical tacrolimus or pimecrolimus will improve PWS therapeutic outcome.

Both topical agents inhibit nuclear factor of activated T-cells (NFAT) which blocks the calcineurin/NFAT pathway inhibiting endothelial cell proliferation and angiogenesis, which could be very useful in preventing PWS recanalization.

The combined use of PDL to induce PWS blood vessel injury, and topical antiangiogenic agents to prevent PWS blood vessel angiogenesis and recanalization after laser therapy, will improve PWS lesion blanching.

Combined Use of Pulsed Dye Laser and Topical Antiangiogenic Agents for Treatment of Port Wine Stain Birthmarks

Beckman Laser Institute University of California Irvine

University of California, Irvine

J S Nelson, M.D., Ph.D.,Professor of Surgery and Biomedical Engineering

Image-guided surgery remove Port Wine Stain

Image-guided remove Port Wine Stain

Bernard Choi, PhD

The researcher develop non-invasive imaging modalities for assessment of port wine stain during laser therapy treatment of Port Wine Stain. The imaging modalities will be used to guide immediate retreatment of regions of persistent perfusion during the procedure.

The researcher can use imaging system operates by projecting low-power near-infrared structured light patterns on to the tissue of interest in a non-contact, reflection geometry and then capturing the reflectance with a camera.The system can image the depth-resolved optical properties of in-vivo tissues, allowing rapid, non-invasive visualization of sub-surface structures of Port Wine Stain.

Monitoring the Response of Port Wine Stain Birthmarks to Laser Therapy With Wide-field Functional Imaging Technologies

Monitoring the Response of Port Wine Stain Birthmarks to Laser Therapy With Wide-field

Bernard Choi, Ph.D., Assistant Professor Biomedical Engineering

Nervous System Diseases

Heart and Blood Diseases

Blood and Lymph Conditions

Hemangioma, Cavernous

Anti-Arrhythmia Agents

Antihypertensive Agents

Herbal and Botanical

Timolol

Maleic acid

Adrenergic beta-Antagonists

Adrenergic Agents

Adrenergic Antagonists

Neurotransmitter Agents

Strawberry

timolol gel 1 to 2 drops twice a day to lesions for 4 months

Apply timolol gel 1-2 drops twice a day to lesion

timolol maleate 0.5% gel

Sheila F Friedlander, MD

We plan to conduct a study, to see how safe and effective timolol maleate 0.5% gel-forming solution is for infantile hemangiomas (IH) and the response of hemangiomas to timolol maleate 0.5% . Our hypothesis is that timolol will inhibit and possibly reverse growth of appropriate infantile hemangiomas.

Subjects will be assigned to open label timolol maleate 0.5%. Parents will be instructed to place 1 to 2 drops twice a day in the center of the hemangioma. Subjects are expected to use the study drug as directed every day for a 4 month period.

Subjects will be assessed at baseline, 2 weeks, 4 weeks, and every 4 weeks thereafter for a total of 5 months. Physical exam, photographs to compare size and color intensity, and a scale of improvement will be completed at each visit. Parents will complete a quality of life questionnaire regarding their child's hemangioma and its impact on quality of life.

Subjects who have evidence of worsening would be removed from the study and transferred to the clinic for evaluation and treatment.

Topical Timolol Gel for the Treatment of Infantile Hemangiomas

At each visit, the size of the IH is assessed in three dimensions (length, width, and height) in cm.

At each visit, the color intensity (e.g., barely perceptible; pale pink or mottled pink/red; red with central pallor; dull red; bright red) of the IH is assessed on a 6 point scale.

A heel stick blood sample is collected to assess for systemic absorption.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Combined Use of Pulsed Dye Laser and Topical Antiangiogenic Agents for Treatment of Port Wine Stain Birthmarks	NCT00969397	Port Wine Stain	Topical Antiang... Pulsed Dye Lase...	16 Years -	University of California, Irvine
Monitoring the Response of Port Wine Stain Birthmarks to Laser Therapy With Wide-field Functional Imaging Technologies	NCT01333553	PORT WINE STAIN	Image-guided re...	1 Day -	University of California, Irvine
Topical Timolol Gel for the Treatment of Infantile Hemangiomas	NCT02145884	Hemangioma	timolol maleate...	7 Days - 6 Months	Rady Children's Hospital, San Diego

Spots Global Cancer Trial Database for birthmark

Every month we try and update this database with for birthmark cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for birthmark

Every month we try and update this database with for birthmark cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for birthmark cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.