Nutritional and Metabolic Diseases

Symptoms and General Pathology

All Conditions

Obesity

Nutrition Disorders

Nutritional intervention will be initiated in patients at risk of overweight and obesity. A targeted nutritional intervention will be carried out, which will include consultation on dietary habits and physical activity as determined by diet and physical activity records. Consultations will be aimed at improving lifestyle and maintaining an adequate body weight.

nutritional interventions

Tomáš Kepák, MUDr.

Lucie Štrublová, Mgr.

Julie Bienertová-Vašků, Prof.

Jan Kučera, Ph.D.

Viera Bajčiová, MUDr.

Hana Hrstková, Prof.

Jaroslav Štěrba, Prof.

NUTRITION CCS is a cross-sectional, descriptive study to assess the relationship between body composition and demographic, socioeconomic status, treatment modalities and blood samples of survivors who were in remission. The study was conducted in the Clinic for childhood cancer survivors. The clinic is attended by patients older than 18 years and was built in 2016 at the St. Anne's Hospital in Brno.

NUTRITION CCS is a cross-sectional, descriptive study to assess the relationship between body composition and demographic, socioeconomic status, treatment modalities and blood samples of survivors who were in remission.

Objectives of the study

1. to determine the prevalence (incidence) of nutritional disorders, especially obesity and metabolic syndrome, in cured paediatric cancer patients in adulthood;
2. to investigate the role of adipokines in the development of cardiometabolic complications in this group of patients; 3. to determine whether targeted dietary and lifestyle interventions can lead to improvements in nutritional status and subjectively perceived quality of life of treated paediatric cancer patients in adulthood and objectively assessed cardiometabolic risk

Patients will undergo analysis of peripheral blood (serum or plasma) or urine including characterization of adipokine profiles/metabolites by targeted or untargeted proteomic approach using mass spectrometry (NanoLC/ESI LTQ-Orbitrap MS/MS) or immunoassays (LUMINEX, ELISA) to identify approximately 15-20 molecules associated with cardiometabolic risk;

Nutrition Childhood Cancer Survivors

Nutritional Status of Cured Pediatric Cancer Patients in Adulthood, the Role of Adipokines in the Development of Cardiometabolic Complications and Desirable Nutritional Interventions

Define the relationship between the levels of selected adipokines and the risk of selected chronic diseases, specifically cardiometabolic diseases.

Determine the number of patients with a high body fat percentage. In these patients, monitor the responses of selected adipokine levels to targeted nutritional intervention leading to fat mass reduction.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Nutrition Childhood Cancer Survivors	NCT05481229	Childhood Cance... Nutrition Disor...	nutritional int...	18 Years - 64 Years	Masaryk University
Nutrition Childhood Cancer Survivors	NCT05481229	Childhood Cance... Nutrition Disor...	nutritional int...	18 Years - 64 Years	Masaryk University
Nutrition Childhood Cancer Survivors	NCT05481229	Childhood Cance... Nutrition Disor...	nutritional int...	18 Years - 64 Years	Masaryk University

Spots Global Cancer Trial Database for children cancer survivors