Neoplasms

Digestive System Diseases

All Conditions

Rare Diseases

Liver Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

Primary Liver Cancer

Hematinics

All Drugs and Chemicals

Liver Extracts

Jie Li, M.D.,Ph.D

Qianqian Chen

Jie Li, M.D., Ph.D

Primary liver cancer (PLC) is the sixth most common malignancy in the world and the third most common cause of malignancy death. In 2020, there were about 905,677 new cases of PLC worldwide, and 830,180 deaths. Despite the availability of a variety of treatments for PLC, the 5-year net survival rate is still only 5% to 30%. How to effectively reduce the disease burden of PLC is a major public health problem that needs to be solved worldwide. The clinical characteristics and prognosis of PLC caused by different pathogenic factors are different. Therefore, it is of great significance to fully identify the risk factors of PLC, be familiar with the clinical characteristics and prognosis of disease development, and understand the relevant monitoring and follow-up strategies for the prevention and treatment of PLC.

Primary liver cancer (PLC) is the sixth most common malignancy in the world and the third most common cause of malignancy death. PLC mainly includes hepatocellular carcinoma (75%-85%) and intrahepatic cholangiocarcinoma (10%-15%). In 2020, there were about 905,677 new cases of PLC worldwide, and 830,180 deaths. Despite the availability of a variety of treatments for PLC, the 5-year net survival rate is still only 5% to 30%. How to effectively reduce the disease burden of PLC is a major public health problem that needs to be solved worldwide. Common risk factors for PLC include Hepatitis B virus (HBV), Hepatitis C virus (HCV) infection, alcohol consumption, metabolic factors, etc. Although antiviral drugs can control or even cure chronic HBV and HCV to a certain extent, chronic viral infection is still the leading cause of PLC worldwide. In addition, with the prevalence of obesity, diabetes and non-alcoholic fatty liver disease (NAFLD), the incidence of non-infectious PLC is gradually increasing. In recent years, NAFLD has gradually become the leading cause of liver transplant waiting list for patients with hepatocellular carcinoma in the United States. The clinical characteristics and prognosis of PLC caused by different pathogenic factors are different. Therefore, it is of great significance to fully identify the risk factors of PLC, be familiar with the clinical characteristics and prognosis of disease development, and understand the relevant monitoring and follow-up strategies for the prevention and treatment of PLC. Currently, there are few large, single-center cohort studies on the clinical features and long-term prognosis of PLC.

Clinical Characteristics of Primary Liver Cancer

A Single Center, Retrospective Clinical Study on the Clinical Characteristics of Primary Liver Cancer

Epidemiological characteristics of overall cohort by liver disease etiology, including HBV, HCV, NAFLD, ALD and others.

Clinical characteristics of overall cohort by liver disease etiology, including HBV, HCV, NAFLD, ALD and others.

1-year, 3-year, 5-year, and 10-year survival rates for overall cohort and different etiologies

Risk factors for recurrence, metastasis, and all cause death in overall cohort and different etiologies

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Principal investigator

Soft Tissue Neoplasms

NO Intervention

Wang Jiaqiang, Dr.

Zhichao Tian, Dr.

It is planned to prospectively collect, collate and report real-world clinical data of BSTS patients treated in our hospital in the next ten years to evaluate the changes in clinical characteristics, treatment patterns and survival information of these patients, in order to provide reference for clinical treatment and research of this type of tumor.

It is planned to prospectively collect, collate and report real-world clinical data of BSTS patients treated in our hospital in the next ten years to evaluate the changes in clinical characteristics, treatment patterns and survival information of these patients, in order to provide reference for clinical treatment and research of this type of tumor. This study is a single-center, prospective, real-world observational study that plans to enroll all eligible patients. Basic information, treatment methods, and prognostic information of these patients were collected.

Study on Clinical Features, Treatment Mode and Survival of Bone and Soft Tissue Tumors

Single-center Real World Prospective Observational Study of Clinical Features, Treatment Patterns, and Survival of Bone and Soft Tissue Tumors

Pathologically confirmed events leading to death

The time from the first use of the treatment to the observation of disease progression

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Clinical Characteristics of Primary Liver Cancer	NCT06325267	Primary Liver C...		18 Years -	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Study on Clinical Features, Treatment Mode and Survival of Bone and Soft Tissue Tumors	NCT05468970	Bone and Soft T... Clinical Featur...	NO Intervention	6 Years - 99 Years	Henan Cancer Hospital
Clinical Characteristics of Primary Liver Cancer	NCT06325267	Primary Liver C...		18 Years -	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Study on Clinical Features, Treatment Mode and Survival of Bone and Soft Tissue Tumors	NCT05468970	Bone and Soft T... Clinical Featur...	NO Intervention	6 Years - 99 Years	Henan Cancer Hospital
Study on Clinical Features, Treatment Mode and Survival of Bone and Soft Tissue Tumors	NCT05468970	Bone and Soft T... Clinical Featur...	NO Intervention	6 Years - 99 Years	Henan Cancer Hospital
Clinical Characteristics of Primary Liver Cancer	NCT06325267	Primary Liver C...		18 Years -	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Spots Global Cancer Trial Database for clinical features