Musculoskeletal Diseases

Nutritional and Metabolic Diseases

All Conditions

Wounds and Injuries

Blood and Lymph Conditions

Neoplasms

Heart and Blood Diseases

Rare Diseases

Osteoporosis

Fractures, Bone

Myeloproliferative Disorders

Polycythemia Vera

Polycythemia

Primary Myelofibrosis

Thrombocytosis

Thrombocythemia, Essential

Bone Marrow Diseases

Hematologic Diseases

Bone Marrow Neoplasms

Hematologic Neoplasms

Blood Platelet Disorders

Hemostatic Disorders

Blood Coagulation Disorders

Hemorrhagic Disorders

Chronic Myeloproliferative Disorders

Sarah Farmer, MD

Hanne Vestergaard, MD

This is a clinical study to evaluate the effect of CMPN (Chronic myeloproliferative neoplasm) to the bone.

The hypothesis is that patients with CMPN have a higher fracture-rate compared to the background population. We expect to find a lower BMD using conventional DXA scan (dual energy x-ray absorptiometry), and a change in other parameters using HR-pQCT (high-resolution peripheral quantitative computerized tomography).Biochemical bone markers is measured to support the hypothesis.

This is a clinical study to evaluate the effect of CMPN to the bone.

Three individual cohorts are defined; a cohort consisting of 50 patients with Polycythemia Vera (PV), a cohort consisting of 50 patients with Essential Thrombocythemia (ET), and a cohort consisting of 25 patients with Primary Myelofibrosis (PMF).

Patients are recruited from the Department of Hematology, Odense University Hospital.

Interventions consist of:

* Conventional DXA scan to measure Bone Mineral Density (BMD).
* Experimental HR-pQCT to assess geometry, strength and microstructure of the bone in 3 dimension.
* Blood-samples are collected and frozen for later analyses of Biochemical Bone Markers: 1-CTP, Ctx, ALP (alkaline phosphatase)and P1NP.

The outcome is compared to healthy control individuals.

Blood samples to compare groups and to look for endocrine abnormalities

Myeloproliferative Neoplasms and Bone Structure

Patients will undergo one DXA scan independent of time of CMPN diagnosis

Patients will undergo one HR.pQCT indepedent of the time of the diagnosis of CMPN

University of Southern Denmark

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Myeloproliferative Neoplasms and Bone Structure	NCT01816022	Polycythemia Ve... Thrombocythemia... Primary Myelofi...		18 Years -	University of Southern Denmark
Myeloproliferative Neoplasms and Bone Structure	NCT01816022	Polycythemia Ve... Thrombocythemia... Primary Myelofi...		18 Years -	University of Southern Denmark

Spots Global Cancer Trial Database for cmpn

Every month we try and update this database with for cmpn cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for cmpn

Every month we try and update this database with for cmpn cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for cmpn cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.