Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Rare Diseases

Prostatic Neoplasms

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

Acute Graft Versus Host Disease

non-exercise control consisting of movie watching.

Exercise

In Canadian men, prostate cancer (PCa) is the most prevalent form of cancer and the third leading cause of cancer-related death. Unfortunately, PCa survivors are often burdened with feelings of anxiety and depression associated with the disease and associated treatments. Short-term exercise interventions (8-24 weeks) have improved psychosocial well-being in this population, but the impact of single bouts of exercise and related psychological or neurological changes have never been studied. The primary objective of the proposed study is to examine the effect of an acute bout of exercise on neurophysiological and psychological indicators of well-being in a randomized controlled trial (RCT) of 36 men with PCa. Participants will be randomly assigned to the intervention (60 min exercise) or control (60 min of television) and will undergo a brief neurological test (cortical silent period) and psychological questionnaires before and after their group assignment.

Acute Effects of Exercise on the Cortical Silent Period in Prostate Cancer Patients

CSP is a measure of cortical inhibition that is negatively related to anxiety, stress, and depression.

Correlations will be assessed between cortical silent period and acute mood state.

Correlations will be assessed between cortical silent period and acute anxiety.

Correlations will be assessed between cortical silent period and acute anxiety and depression.

Correlations will be assessed between cortical silent period and exercise-induced feelings.

University of Guelph-Humber

Assistant Program Head, Kinesiology

Serious adverse and other adverse events were collected during participants' activity in the trial (i.e. the pre-treatment assessment, during the exercise or video sessions, and during the post-treatment assessment).

Control

Total

Age, Categorical

Age, Continuous

Sex: Female, Male

Canada

Region of Enrollment

Dr. Daniel Santa Mina

Change From Baseline in Cortical Silent Period (CSP) Will be Determined Using Transcranial Magnetic Stimulation (TMS) of the Motor Cortex.

Profile of Mood States Questionnaire(PoMS)

State-Trait Anxiety Inventory - Questionnaire(STAI)

Hospital Anxiety and Depression Scale - Questionnaire(HADS)

Exercise-Induced Feelings Inventory - Questionnaire (EIFI)

non-exercise control consisting of movie watching for 60 mins. the videos were short cartoon films considered to be emotionally neutral.

Control (1hr of Viewing Emotionally Neutral Movie)

1 hour of moderate intensity exercise. The session included 5- min warm-up, 25-min of resistance training, 25-min of aerobic training, and 5-min cool-down. Each session was led by a personal trainer and supervised by an exercise physiologist.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Acute Effects of Exercise on the Cortical Silent Period in Prostate Cancer Patients	NCT01715064	Prostate Cancer	Exercise	45 Years - 85 Years	University of Guelph-Humber
Acute Effects of Exercise on the Cortical Silent Period in Prostate Cancer Patients	NCT01715064	Prostate Cancer	Exercise	45 Years - 85 Years	University of Guelph-Humber

Spots Global Cancer Trial Database for cortical silent period