Symptoms and General Pathology

All Conditions

Nausea

Vomiting

Signs and Symptoms, Digestive

Antineoplastic Agents

All Drugs and Chemicals

Carboplatin

All patients will be given the Functional Living Index - Emesis (FLIE) standardized questionnaire during their scheduled clinic visit prior to receiving chemotherapy.

This is a self-administered questionnaire. Patients will complete the questionnaire during the 5 days following carboplatin administration (at 24 hours, 48 hours, 72 hours, and 96 hours) of their first and third cycles of chemotherapy.

Patients will also be interviewed by a trained CRA or research nurse over the telephone 24-48 hours following carboplatin administration in order to assess the severity of the delayed nausea and vomiting.

Functional Living Index - Emesis

Maria Q Baggstrom, M.D.

Delayed emesis following administration of carboplatin-based chemotherapy despite prophylaxis with standard antiemetic prophylaxis (5-HT3 and corticosteroid) remains a clinically significant and distressing problem for patients with cancer. The incidence of delayed emesis appears to be higher in women compared to men.

All patients will be given the Functional Living Index- Emesis (FLIE), a standardized questionnaire. This is a self-administered questionnaire to assess the impact of nausea and vomiting on the patient's functional living, including physical activities, social and emotional function, and ability to enjoy food and drink. Patients will complete the questionnaire during the 5 days following carboplatin administration (at 24 hours, 48 hours, 72 hours and 96 hours) during their first and third cycles of chemotherapy. The questionnaire should take approximately 10 minutes or less to complete.

Patients will also be interviewed by a trained CRA or research nurse over the telephone 24-48 hours following carboplatin administration in order to assess the severity of the delayed nausea and vomiting.

Observational Study of Delayed Nausea and Vomiting

Observational Study of Delayed Nausea and Vomiting Following Administration of Carboplatin Containing Regimens for Treatment of Cancer

Despite appropriate administration of standard 5-HT3 receptor antagonist antiemetic prophylaxis after the first cycle of chemotherapy.

Despite appropriate administration of standard antiemetic prophylaxis after the third cycle of chemotherapy

Despite appropriate administration of standard antiemetic prophylaxis.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Observational Study of Delayed Nausea and Vomiting	NCT00696280	Vomiting	Functional Livi...	18 Years -	Washington University School of Medicine
Observational Study of Delayed Nausea and Vomiting	NCT00696280	Vomiting	Functional Livi...	18 Years -	Washington University School of Medicine
Observational Study of Delayed Nausea and Vomiting	NCT00696280	Vomiting	Functional Livi...	18 Years -	Washington University School of Medicine

Spots Global Cancer Trial Database for delayed emesis following treatment with carboplatin