Nervous System Diseases

All Conditions

Nutritional and Metabolic Diseases

Gland and Hormone Related Diseases

Immune System Diseases

Behaviors and Mental Disorders

Eye Diseases

Diseases and Abnormalities at or Before Birth

Neoplasms

Skin and Connective Tissue Diseases

Symptoms and General Pathology

Rare Diseases

Parkinson Disease

Diabetes Mellitus

Diabetes Mellitus, Type 1

Alzheimer Disease

Macular Degeneration

Huntington Disease

Parkinsonian Disorders

Ganglion Cysts

Synovial Cyst

Basal Ganglia Diseases

Brain Diseases

Central Nervous System Diseases

Movement Disorders

Synucleinopathies

Neurodegenerative Diseases

Dementia

Tauopathies

Neurocognitive Disorders

Mental Disorders

Psychotic Disorders

Retinal Degeneration

Retinal Diseases

Metabolic Diseases

Glucose Metabolism Disorders

Endocrine System Diseases

Autoimmune Diseases

Chorea

Dyskinesias

Heredodegenerative Disorders, Nervous System

Genetic Diseases, Inborn

Cognition Disorders

Familial Alzheimer Disease

Biological sample collection for biobanking and research

Biological sample collection

Scott Noggle, PhD

The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to study different conditions and diseases by using cells from the body (such as skin or blood cells). NYSCF uses these samples to make stem cells and other types of cells, conduct research on the samples, perform genetic testing, and/or store these samples for future use.

Through this research, scientists hope to identify future treatments or even cures.

Researchers at NYSCF study diverse diseases, conditions, and traits by creating "pluripotent" stem cells. These stem cells can become any cell in the human body, including cells that may be difficult, invasive, or even impossible to obtain directly. For example, researchers may create pancreatic insulin-producing cells to learn more about type 1 diabetes, or brain cells to learn more about Parkinson's disease.

Additionally, researchers perform genetic testing to learn more about DNA, a material in most cells that contains instructions for the body's development and functions (such as traits like eye color and risk of certain diseases). A piece of DNA that determines the specific role of a cell is called a "gene." If the instructions in a gene are abnormal, this can lead to disease.

Participation in the study involves: (1) completion of a health questionnaire, (2) providing a skin and/or blood sample from which stem cells may be created, (3) possible collection of a saliva sample for genetic analysis, and (4) possible future follow-up to provide additional information or learn about other research studies.

This study is not a clinical trial.

Skin biopsy (2-3mm) and/or blood (up to 50 mL); saliva; excess/leftover biospecimens that were (or will be) collected for other purposes (e.g., medical procedure)

Biological Sample Collection for Research and Biobanking

There are no primary endpoints planned for this biobank; endpoints will be specific to research projects that utilize samples/data contained in the biobank. Projects may investigate the biology, etiology, manifestations, progression, risk factors, genetic underpinnings, and treatment of diseases, conditions, and traits.

Laser and Skin Surgery Center of New York

New York Stem Cell Foundation Research Institute

Senior Vice President, Research

Digestive System Diseases

Neoplasm Metastasis

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Hematinics

All Drugs and Chemicals

Herbal and Botanical

Liver Extracts

Cola

Ayala Hubert, MD

Hadas Lemburg, PhD

Arik Tzukert, DMD

Rinat Abramovitch, PhD

Leo Joskowicz, PhD

Abramovitch Rinat, PhD

Joskowicz Leo, PhD

The purpose of this protocol is to develop a detailed MRI technique and haemodynamic maps enabling early detection of colorectal metastases in the liver.

In this research, we propose to develop methods and protocols for imaging-based, non-invasive early detection and diagnosis of colon cancer metastases. Colon cancer is the third most common cancer worldwide. While it is amenable to surgery if detected early, advanced carcinomas are usually lethal, with liver metastases being the most common cause of death. Early and accurate detection of these lesions is recognized as having the potential of improving survival rates and reducing treatment morbidity. Current diagnostic imaging offers improved discrimination and sensitivity that can be used for earlier detection of smaller lesions conducive to curative therapy.

In previous research, we demonstrated the feasibility of fMRI based on hypercapnia and hyperoxia for monitoring changes in liver perfusion and hemodynamics without contrast agent administration. The isolation and analysis of areas with significant hemodynamical changes in images acquired at early phase of tumor development has proven to be a difficult, time consuming, and potentially unreliable task. Our goal is thus two-fold: 1. use image processing and machine learning tools on a training set of hemodynamical maps obtained from well validated tumors to automate the process and improve its discrimination and sensitivity characteristics, and; 2. implement our method in patients with colorectal liver metastases. The method can help general radiologists with no image processing training to highlight undetectable tumors from background noise and increase diagnosis specificity and sensitivity.

Computer Assisted Early Detection of Liver Metastases From fMRI Maps

Hadassah Medical Organization

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Biological Sample Collection for Research and Biobanking	NCT04270604	Parkinson Disea... Diabetes Mellit... Macular Degener... ALS Cancer Alzheimer Disea... Huntington Dise...	Biological samp...	1 Month - 100 Years	New York Stem Cell Foundation Research Institute
Biological Sample Collection for Research and Biobanking	NCT04270604	Parkinson Disea... Diabetes Mellit... Macular Degener... ALS Cancer Alzheimer Disea... Huntington Dise...	Biological samp...	1 Month - 100 Years	New York Stem Cell Foundation Research Institute
Biological Sample Collection for Research and Biobanking	NCT04270604	Parkinson Disea... Diabetes Mellit... Macular Degener... ALS Cancer Alzheimer Disea... Huntington Dise...	Biological samp...	1 Month - 100 Years	New York Stem Cell Foundation Research Institute
Computer Assisted Early Detection of Liver Metastases From fMRI Maps	NCT00435097	Metastatic Colo...		20 Years -	Hadassah Medical Organization

Spots Global Cancer Trial Database for disease modeling