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Eriodictyol

Patients consumed a polyphenol-rich dietary supplement (commercial lemon, orange, pomegranate, olive, grape, cocoa, curcuma and broccoli extracts), mainly rich in simple phenolics such as hydroxytyrosol and the polyphenols procyanidins, hesperidin, eriocitrin, curcumin, resveratrol, punicalagin and ellagic acid. Cocoa extract also contains the methylxanthines theobromine and caffeine.

Participating patients did not consume the supplement but provided biological samples to the trial

Patients consume 3 capsules/day (474 mg phenolics/day) from the biopsy-confirmed breast cancer diagnosis to the surgery

Polyphenol

Juan C. Espín, PhD

The aim is to characterise the metabolic profiling of dietary polyphenols in normal and malignant breast tissues from breast cancer patients.

The objective of this exploratory trial is to determine the disposition and characterise the metabolic profiling of dietary polyphenols in normal and malignant glandular breast tissues from newly diagnosed breast cancer patients.

The patients consumed a polyphenol-rich dietary supplement containing 37 different phenolics and 2 methylxanthines (theobromine and caffeine) from the diagnosis to the surgery. The metabolic profiling was characterized in normal and malignant breast tissues as well as plasma and urine using UPLC-ESI-QTOF-MS/MS.

Randomised, parallel-controlled dietary intervention

Disposition of Dietary Polyphenols and Methylxanthines in Mammary Tissues From Breast Cancer Patients

Metabolic Profiling of Dietary Polyphenols and Methylxanthines in Normal and Malignant Mammary Tissues From Breast Cancer Patients

Quantification of dietary polyphenols and methylxanthines in normal and malignant mammary tissues from breast cancer patients using ultra-high resolution liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry (UPLC-ESI-QTOF-MS/MS).

* Quantification (pmol/g) of each phenolic-derived metabolite in breast tissues.
* Quantification (pmol/g) of each methylxanthine-derived metabolite in breast tissues.

Quantification of dietary polyphenols and methylxanthines in urine and plasma from breast cancer patients using ultra-high resolution liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry (UPLC-ESI-QTOF-MS/MS).

* Quantification of each phenolic-derived metabolite in urine and plasma (nmol/L).
* Quantification of each methylxanthine-derived metabolite in urine and plasma (nmol/L).

Hospital General Universitario Reina Sofía de Murcia

National Research Council, Spain

Research Professor

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Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Disposition of Dietary Polyphenols and Methylxanthines in Mammary Tissues From Breast Cancer Patients	NCT03482401	Breast Cancer	Polyphenol	18 Years -	National Research Council, Spain
Disposition of Dietary Polyphenols and Methylxanthines in Mammary Tissues From Breast Cancer Patients	NCT03482401	Breast Cancer	Polyphenol	18 Years -	National Research Council, Spain
Disposition of Dietary Polyphenols and Methylxanthines in Mammary Tissues From Breast Cancer Patients	NCT03482401	Breast Cancer	Polyphenol	18 Years -	National Research Council, Spain

Spots Global Cancer Trial Database for disposition

Every month we try and update this database with for disposition cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for disposition cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.