Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Lung Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Audit

Aliae Mohamed-Hussein, MD

The investigators will conduct nationally representative survey in chest physicians in Egypt in 2016-2017. Self-administered questionnaire will be used to assess the physicians' knowledge of lung cancer screening guidelines, beliefs about the effectiveness of screening tests, and ordering of screening chest radiography, low-dose spiral computed tomography, or sputum cytology in the past 12 months.

Although current practice guidelines do not recommend screening asymptomatic patients for lung cancer, physicians may still order lung cancer screening tests. No recent national survey of health care professionals has focused on lung cancer screening

Audit of Lung Cancer Screening Practice in Chest Physicians: An Update

Lung Cancer Screening Practice in Chest Physicians

Assiut University

Prof. Dr. Aliae AR Mohamed-Hussein, Professor of Pulmonology

Digestive System Diseases

Liver Diseases

Gastrointestinal Diseases

Antineoplastic Agents

All Drugs and Chemicals

Hematinics

Anticoagulants

Paclitaxel

Albumin-Bound Paclitaxel

Liver Extracts

Edetic Acid

Pentetic Acid

Plasma concentrations of paclitaxel and its metabolites will be obtained during the first treatment cycle. The samples for paclitaxel analysis will be collected in ethylenediamine tetraacetic acid tubes at 7-time points: just before infusion, in the middle of the infusion, at the end of infusion, at 1, 2, 4 and 6 hours post-infusion.

Blood samples

Ahmed M Mohamed, Master

Ahmed Nour-Eldin, Professor

Khaled Abdel-Aziz, MD

The study aims to assess the pharmacokinetics of paclitaxel and its two major metabolites in patients with normal and impaired liver functions.

population pharmacokinetic study in patients with normal or impaired liver functions, receiving paclitaxel for cancer treatment.

40 Patients with histologically confirmed solid tumors will be enrolled in the study:

* 20 patients have normal liver functions as defined by transaminase \< 2.6 x ULN and bilirubin values \< 1.26 x ULN.
* 20 patients with liver impairment as defined by transaminase 2.6 - 10 x ULN and bilirubin values 1.26 - 5 x ULN.

Pharmacokinetics of Paclitaxel in Correlation With Adverse Events in Cancer Patients With and Without Liver Impairment

Effect of CYP3A4 and CYP2C8 Activity on Pharmacokinetics of Paclitaxel, Correlation With Adverse Events in Cancer Patients With and Without Liver Impairment

determination of plasma concentration and pharmacokinetic analysis of paclitaxel

determination of plasma concentration and pharmacokinetic analysis of 6-α-hydroxypaclitaxel

determination of plasma concentration and pharmacokinetic analysis of 3'-p-hydroxypaclitaxel

metabolite ratio of 6-α-hydroxypaclitaxel/paclitaxel

metabolite ratio of 3'-p-hydroxypaclitaxel/paclitaxel

Complete blood count, liver functions and neuropathy evaluation (according to Common Terminology Criteria for Adverse Events (CTCAE), version 5) will be assessed

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Audit of Lung Cancer Screening Practice in Chest Physicians: An Update	NCT02944903	Lung Cancer Scr...	Audit	-	Assiut University
Pharmacokinetics of Paclitaxel in Correlation With Adverse Events in Cancer Patients With and Without Liver Impairment	NCT04863144	Liver Diseases	Blood samples	18 Years - 70 Years	Ain Shams University
Pharmacokinetics of Paclitaxel in Correlation With Adverse Events in Cancer Patients With and Without Liver Impairment	NCT04863144	Liver Diseases	Blood samples	18 Years - 70 Years	Ain Shams University
Audit of Lung Cancer Screening Practice in Chest Physicians: An Update	NCT02944903	Lung Cancer Scr...	Audit	-	Assiut University

Spots Global Cancer Trial Database for egypt

Every month we try and update this database with for egypt cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for egypt

Every month we try and update this database with for egypt cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for egypt cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.