Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Breast Neoplasms

Erik F Young, Ph.D.

The objective of the present study is to determine whether or not primary human mammary epithelial cells are competent for use in molecular studies of transepithelial electrophysiology focusing on the function of the tight junction protein claudin 3.

Human breast Tissue will be removed from mastectomy specimens and used as a source to generate epithelial cells for study.

The Biology of Claudin 3 in Primary Human Mammary Epithelial Cell Culture

Hackensack Meridian Health

Nutritional and Metabolic Diseases

Gland and Hormone Related Diseases

Nervous System Diseases

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Rare Diseases

Adenoma

Diabetes Mellitus

Pituitary Diseases

Diabetes Insipidus, Neurogenic

Diabetes Insipidus

Pituitary Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Hypothalamic Diseases

Brain Diseases

Central Nervous System Diseases

Endocrine System Diseases

Endocrine Gland Neoplasms

Hypothalamic Neoplasms

Supratentorial Neoplasms

Brain Neoplasms

Central Nervous System Neoplasms

Nervous System Neoplasms

Kidney Diseases

Urologic Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Male Urogenital Diseases

Central Diabetes Insipidus

Patients undergoing the extra intra-operative electrophysiological measurement

Electrophysiological measurement with single-unit micro-electrode

Micro-electrode measurement

Measurment of electrophysiological properties of the human pituitary gland during removal of a pituitary adenoma. Assessment if these properties are sufficient for intra-operative identification of different tissues.

In this study, patients undergoing a surgical resection of a pituitary adenoma as part of standard care will undergo an extra measurement of the electrophysiological properties of the pituitary gland. A single-unit microlectrode will be introduced and placed in the adenoma tissue, anterior piuitary lobe and posterior pituitary lobe. Apart from this measurement, no other interventions are performed and standard care will continue. Six months after measurements the patients chart will be assessed for the occurrence of remission and endocrine deficiencies.

An assessment will be made if these properties are distinctive enough to allow intra-operative identification of the different tissues and thereby increase chances of maximal tumour removal and decrease chance of endocrine deficiencies.

Electrophysiology of the Human Pituitary Gland

Identification of the Posterior Lobe of the Human Pituitary Gland During Surgery Using Its Electrophysiological, Neural Signature

Electrophysiological properties of the human pituitary gland

Occurrence of endocrine remission after surgery

Occurrence of endocrine deficiencies after surgery

Leiden University Medical Center

MD, PhD

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
The Biology of Claudin 3 in Primary Human Mammary Epithelial Cell Culture	NCT00481585	Breast Cancer		-	Hackensack Meridian Health
Electrophysiology of the Human Pituitary Gland	NCT05338125	Pituitary Adeno... Pituitary Tumor Diabetes Insipi... Endocrine; Defi...	Micro-electrode...	18 Years -	Leiden University Medical Center
Electrophysiology of the Human Pituitary Gland	NCT05338125	Pituitary Adeno... Pituitary Tumor Diabetes Insipi... Endocrine; Defi...	Micro-electrode...	18 Years -	Leiden University Medical Center

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