Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Symptoms and General Pathology

Nervous System Diseases

Wounds and Injuries

Carcinoma, Non-Small-Cell Lung

Emergencies

Lung Neoplasms

Death

Spinal Cord Compression

Disease Attributes

Spinal Cord Diseases

Central Nervous System Diseases

Spinal Cord Injuries

emergency radiotherapy within 12 hours after neurological deficit due to MSCC

external beam radiotherapy

Acute neurological deficit in metastatic spinal cord compression is an emergency condition in radiation oncology. Despite some reports about the high efficacy of radiation treatment for oncological emergencies, a standard of care is not well defined, especially the time interval of immediate RT after deficit, and neurological outcome with respect to poor survival in non-small cell lung cancer patients. The objective of this trial is to investigate neurological outcome after emergency radiotherapy in metastatic spinal cord compression of non-small cell lung cancer patients with acute neurological deficit.

Subjects and recruitment 15 consecutive patients with histologically confirmed non-small cell lung cancer and bone metastases of the thoracic or lumbar segments of the vertebral column will be screened for this trial in the Radiooncology Department of the Heidelberg University Clinic. Inclusion criteria are an age of 18 to 80 years, acute neurological symptom caused by metastatic spinal cord compression, no radiotherapy in this spinal area before, and written consent to participate.

Design and procedures This is a prospective, controlled, explorative trial to investigate the neurological outcome after emergency radiotherapy in metastatic spinal cord compression of non-small cell lung cancer patients with acute neurological deficit. RT start within 12 hours after onset of neurological symptoms. The target parameters will be measured at the start of radiotherapy (t0), and six weeks after radiotherapy (RT) (t1). The target parameters comprise the documentation and completion of the ASIA Impairment Scale (AIS), and the recording of patient-specific data.

Emergency Radiotherapy in Metastatic Spinal Cord Compression of Patients With Non-small Cell Lung Cancer

Phase 1 Study of Neurological Outcome After Emergency Radiotherapy in Metastatic Spinal Cord Compression

The primary endpoint was neurological outcome, assessed using the ASIA Impairment Scale (AIS)

according CT scan, local control will be assessed

Heidelberg University

Neurological outcome after emergency radiotherapy in MSCC of patients with non-small cell lung cancer

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Emergency Radiotherapy in Metastatic Spinal Cord Compression of Patients With Non-small Cell Lung Cancer	NCT02000518	Neurological Ou... Survival From F...	external beam r...	18 Years - 80 Years	Heidelberg University
Emergency Radiotherapy in Metastatic Spinal Cord Compression of Patients With Non-small Cell Lung Cancer	NCT02000518	Neurological Ou... Survival From F...	external beam r...	18 Years - 80 Years	Heidelberg University

Spots Global Cancer Trial Database for emergency radiotherapy