Neoplasms

All Conditions

Respiratory Tract (Lung and Bronchial) Diseases

Carcinoma

Lung Neoplasms

Carcinoma, Bronchogenic

Bronchial Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Control arm: Current practice for diagnosing and staging lung cancer. Most patients with intra-thoracic disease suspected of lung cancer will undergo bronchoscopy (or CT guided biopsy), PET scan and possibly mediastinoscopy.

Active arm: A new pathway for the diagnosis and staging of lung cancer with endobronchial (EBUS) or endoscopic ultrasound (EUS) as a first test. If EBUS or EUS is negative the patient will have PET scan +/- mediastinoscopy.

Patients with anterior mediastinal or subcarinal disease will undergo EBUS. Patients with posterior, subcarinal or AP window disease will undergo EUS. Patients with no mediastinal disease on CT scan will undergo EBUS.

Endobronchial or Endoscopic Ultrasound

Investigations will be determined by the multi-disciplinary team responsible for the patient

Bronchoscopy, CT-guided biopsy, PET scan, Mediastinoscopy

Stephen Spiro, MD

Sam Janes, MD PhD

Neal Navani, MD

In the UK, staging of lung cancer is time consuming (taking on average more than 3 weeks), costly and inaccurate in up to 20% of cases. The investigators wish to determine whether using the newer techniques of endobronchial ultrasound (EBUS) and endoscopic ultrasound (EUS) improves lung cancer staging. The investigators' hypothesis is that EUS (endoscopic ultrasound) or EBUS (endobronchial ultrasound guided transbronchial needle aspirate) as a first test after CT scan in the diagnosis and staging of lung cancer will result in a reduction in the time from first outpatient appointment to treatment decision, a reduction in the total number of scans and investigative operations, fewer outpatient attendances and a reduction in healthcare costs.

A New Pathway With BronchOscopic or Oesophageal Ultrasound for Lung Cancer Diagnosis and STaging (BOOST)

A Randomized Controlled Trial of Endobronchial or Endoscopic Ultrasound as a First Test in the Diagnosis and Staging of Lung Cancer

North Middlesex University Hospital

Barnet and Chase Farm Hospitals NHS Trust

The Whittington Hospital NHS Trust

University College London Hospitals

Reader in Respiratory Medicine

Dedicated ultrasonographic probe during bronchoscopy

François TRANQUART, PR

The exploration of neoplastic pulmonary pathology is based on computed tomography and bronchoscopy. This allows targeted samples of the identified lesions.

A new ultrasonographic method is proposed as a non invasive and non irradiating technic by using a dedicated probe easily introduced via the channel of the fibrescope, so as to complete the identification of peripheral lesions.

The main objective of the study is to assess the ability of endobronchial ultrasonography to diagnose peripheral pulmonary lesions during the bronchoscopy and to correlate the abnormalities to computed tomography and/or histology.

The dedicated probe consist of a linear array of 2-3 mm in diameter connected to a commercial unit.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
A New Pathway With BronchOscopic or Oesophageal Ultrasound for Lung Cancer Diagnosis and STaging (BOOST)	NCT00652769	Bronchogenic Ca...	Endobronchial o... Bronchoscopy, C...	18 Years -	University College London Hospitals
Bronchial Ultrasonography Via a Fibrescope: Pilot Study in Tumoral Disease	NCT00241267	Pulmonary Neopl...	Dedicated ultra...	18 Years -	University Hospital, Tours
A New Pathway With BronchOscopic or Oesophageal Ultrasound for Lung Cancer Diagnosis and STaging (BOOST)	NCT00652769	Bronchogenic Ca...	Endobronchial o... Bronchoscopy, C...	18 Years -	University College London Hospitals
Bronchial Ultrasonography Via a Fibrescope: Pilot Study in Tumoral Disease	NCT00241267	Pulmonary Neopl...	Dedicated ultra...	18 Years -	University Hospital, Tours
Bronchial Ultrasonography Via a Fibrescope: Pilot Study in Tumoral Disease	NCT00241267	Pulmonary Neopl...	Dedicated ultra...	18 Years -	University Hospital, Tours

Spots Global Cancer Trial Database for endobronchial