Symptoms and General Pathology

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Neoplasms

Gland and Hormone Related Diseases

Syndrome

Infertility

Polycystic Ovary Syndrome

Anovulation

Genital Diseases

Urogenital Diseases

Cysts

Ovarian Cysts

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Gonadal Disorders

Endocrine System Diseases

Endometrial Currettage (endometrial scrapping) will be performed at the time of laparoscopic ovarian drilling

No endometrial curettage at time of Laparoscopic ovarian drilling

Only Laparoscopic ovarian drilling without endometrial currettage will be performed

Endometrial Currettage

Ahmed Gibreel, MD

Laparoscopic Ovarian Drilling is a valid procedure for infertile anovulatory women with polycystic ovarian syndrome who failed to get pregnant or to ovulate with ovulation induction medications as clomiphene citrate or exogenous gonadotropins. The reasearchers supposed that endometrial curettage at time of laparoscopic ovarian drilling may boost fertility in these women.

Current literature suggests that endometrial biopsy may improve pregnancy rates in infertile women hence the investigators will examine whether this hypothesis will apply to infertile PCOS women undergoing laparoscopic ovarian drilling to overcome ovulatory disfunction or not.

Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women

Endometrial Scratching at Time of Laproscopic Ovarian Drilling in Women With Anovulatory Infertility Due to Polycystic Ovarian Syndrome (PCOS): Randomized Controlled Trial.

Mansoura University

Skin and Connective Tissue Diseases

Leiomyoma

Myofibroma

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Neoplasms, Connective Tissue

Connective Tissue Diseases

Women with submucosal leimyomas undergoing hysteroscopical removal of the leiomyoma

Women with intramural leiomyomas undergoing myomectomy

Patients treated at the Department for Reproductive Medicine at the Oslo University hospital failing to conceive after 3 or more embryo transfers with good quality embryos.

Healthy, volunteering women with proved fertility with 1 or more deliveries and no history of infertility

Transcervical resection of fibroids

Myomectomy per laparoscopy or laparotomy

Thea F. Mikkelsen, MD

Kirsten Hald, PhD

Thea F Mikkelsen, MD

We aim to explore some of the molecular factors that reduce fertility for women with leiomyomas, taking into account leiomyoma location, size, number and vascularity. Tissue samples from the endometrium and leiomyomas will be obtained during the mid secretory phase before and 3-6 months after surgical excision for a comprehensive search for key molecular derangements.

Baseline medical information and standard questionnaire to record symptoms are collected from all participants and a gynaecological examination and a 2D and 3D vaginal ultrasonography including saline infusion sonography (SIS), if indicated, are performed. Blood samples for the biobank for extraction of germ line DNA and for identification of possible biomarkers are taken.

The women with submucosal leiomyomas will undergo hysteroscopic myomectomy and the women with intramural leiomyomas will undergo myomectomy per laparoscopy or laparotomy.

For the participants with intramural leiomyomas and the fertile/infertile controls, endometrial samples are taken with an endometrial suction curette in an outpatient setting at day 19-23 of the menstrual cycle. The endometrial sampling in the group of women with submucosal leiomyomas is being done during the hysteroscopic removal of the leiomyoma, also at day 19-23 of the menstrual cycle.

3-6 months after surgery, cycle day 19-23, endometrial samples will be taken from the women who have undergone myomectomy and ultrasound examination is being performed. The women with submucosal leiomyomas will undergo a second look hysteroscopy

Endometrial biopsies Leiomyoma biopsy Serum Plasma Blood cells

The biological sex must be female since we are studying a phenomenone occuring in the female genital tract.

Fibroids and Infertility - a Study of the Significance of Removal of Fibroids With Regard to Endometrial Receptivity

Mechanisms of Reduced Fertility in Women With Uterine Leiomyomas

Fold change of HOXA 10 Expression 3-6 months after myomectomy compared to pre-surgery Levels

Fold change of other molecular markers than HOXA 10 of endometrial receptivity 3-6 months after myomectomy and compared to fertile/infertile controls

VI and FI of the endometrium and subendometrial myometrium of women with leimyomas 3-6 months after myomectomy and compared to fertile/infertile controls

Vascular characteristics of leiomyomas associated with endometrial changes

Leiomyomas size in centimeters associated with endometrial changes

Leiomyoma location associated with endometrial changes

Genomic characteristics of leiomyomas associated with endometrial changes

Scar/fibrosis/adhesion formation after myomectomy; macroscopically and histologically

Pregnancy and deliveries within 2 years after myomectomy.

Difference in HOXA 10 expression in endometrium of women with leiomyomas compared to fertile/infertile controls

Difference in expression of molecular markers in endometrium adjacent to the leiomyoma compared to endometrium remote from the leiomyoma.

Alterations in molecular markers of endometrial receptivity after partially resected submucosal leiomyomas.

Difference in expression of molecular markers in endometrium of women with submucosal leiomyomas compared with endometrium in women with intramural leiomyomas.

Biomarkers in blood related to leiomyomas and a possible correlation between certain biomarkers and reduced endometrial receptivity.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women	NCT02140398	Infertility Polycystic Ovar...	Endometrial Cur...	18 Years - 39 Years	Mansoura University
Fibroids and Infertility - a Study of the Significance of Removal of Fibroids With Regard to Endometrial Receptivity	NCT04426760	Leiomyoma, Uter...	Transcervical r... Myomectomy per ...	18 Years - 40 Years	Oslo University Hospital

Spots Global Cancer Trial Database for endometrial receptivity