Neoplasms

All Conditions

Symptoms and General Pathology

Mouth and Tooth Diseases

Ear, Nose, and Throat Diseases

Rare Diseases

Carcinoma

Recurrence

Nasopharyngeal Carcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Disease Attributes

Nasopharyngeal Neoplasms

Pharyngeal Neoplasms

Otorhinolaryngologic Neoplasms

Head and Neck Neoplasms

Nasopharyngeal Diseases

Pharyngeal Diseases

Stomatognathic Diseases

Otorhinolaryngologic Diseases

143 participants in group 1 will undergo endoscopic surgery

143 participants in group 2 will undergo radiation therapy(IMRT)

143 patients will undergo endonasal endoscopic surgery

endonasal endoscopic surgery

143 patients will undergo radiation therapy.

radiation therapy(IMRT)

Xiaole Song, MD

Zhihui Pang

Desheng Wang, MD

Haichun Lai, MD

Desheng Wang

Jing Ye, MD

Jing Ye

Lin Kong, MD

Jiyi Hu, MD

Lin Kong

Hongmeng Yu, MD

This study is a multicenter RCT to compare 3-year overall survival(OS) rate, progression free survival(PFS),local progression free survival(LPFS),regional progression free survival(RPFS),distant metastasis free survival(DMFS), and toxicities of endonasal endoscopic surgery versus IMRT.

Local and regional recurrence is a common cause of failure after primary radiotherapy for nasopharyngeal carcinoma. Radiotherapy and surgery are the treatments of choice for recurrent NPC. This study aims to compare 3 year overall survival(OS) rate of surgery versus IMRT.A stratified-block randomized approach will be used to randomly assign patients into two treatment groups after stratification according to N staging (N0 vs non-N0). Patients with rNPC will be recruited and randomized into two groups in 1:1 ratio. The primary outcomes will be 3 year overall survival(OS), the secondary outcome measures will be PFS,LPFS,RPFS,DMFS,and toxicities.Assessment will be performed at baseline and during 3 years post-randomization.

Early Recurrent Nasopharyngeal Cancer: the Effect of Surgery vs IMRT

A Multicenter Randomized Controlled Trial for Comparing Endonasal Surgery and Radiation Therapy (IMRT) for T1-T2 Recurrent Nasopharyngeal Carcinoma

using European Organisation for Research and Treatment of Cancer quality of life questionaire（EORTC QLQ）- H\&N35，All of the scales and single-item measures range in score from 0 to 100. For all the scales and single-items a high score represents a high level of symptomatology or problems.

using European Organisation for Research and Treatment of Cancer quality of life questionaire（EORTC QLQ) - C30 version3.0. All of the scales and single-item measures range in score from 0 to 100. A high scale score represents a higher response level.

The proportion of patients who survived 3 years

the time from randomization to the first recording of disease progression or death from any cause.

the time from randomization to local failure or death

From randomization to regional failure or death

From randomization to distant metastasis or death

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Early Recurrent Nasopharyngeal Cancer: the Effect of Surgery vs IMRT	NCT04215510	Recurrent Nasop...	endonasal endos... radiation thera...	18 Years - 70 Years	Eye & ENT Hospital of Fudan University
Early Recurrent Nasopharyngeal Cancer: the Effect of Surgery vs IMRT	NCT04215510	Recurrent Nasop...	endonasal endos... radiation thera...	18 Years - 70 Years	Eye & ENT Hospital of Fudan University

Spots Global Cancer Trial Database for endonasal endoscopic surgery