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Myeloproliferative Disorders

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Thrombocythemia, Essential

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Chronic Myeloproliferative Disorders

Essential Thrombocythemia

Josef Prachal, MD

Myeloproliferative disorders occur in families, thus giving rise to the theory that it is a genetic disease that may be caused by an abnormal gene in the DNA that can be passed from one generation of family members to another. DNA can be gathered from family members through blood samples and the investigators will investigate (through DNA testing) to see if there are abnormal genes that may be responsible for causing the MPDs. Understanding which genes are responsible for causing MPDs can help develop ways to identify people who may be at risk for developing an MPD, allow for the development of better treatments, possibly a cure, or even prevent the development of MPDs.

Blood samples from subjects and family members with myeloproliferative disease.

Familial Myeloproliferative Disorders

Molecular Biology of Familial Myeloproliferative Disorders

Myeloproliferative Disorders-Research Consortium

National Cancer Institute (NCI)

Icahn School of Medicine at Mount Sinai

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Familial Myeloproliferative Disorders	NCT00666289	Polycythemia Ve... Essential Throm... Idiopathic Myel...		7 Years -	Icahn School of Medicine at Mount Sinai
Familial Myeloproliferative Disorders	NCT00666289	Polycythemia Ve... Essential Throm... Idiopathic Myel...		7 Years -	Icahn School of Medicine at Mount Sinai

Spots Global Cancer Trial Database for family clusters