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All the Low dose computed tomography of lung was performed with 64 slices multidetectors CT in single hold breath covering entire lung. The protocol of scanning parameters (120KVp, 40-80 mA, 1.25 mm or less in thickness) was standardized. The raw data would be reconstructed to axial images (3 mm thickness and interval) and coronal images (3 mm thickness and interval). The scan should be finished in a single breath (15-20 second) from the thoracic inlet to adrenal glands.

Participants will receive 3 round of low dose computed tomography screening every year

low dose computed tomography

Gee-Chen Chang, MD, PhD

Screening with the use of low-dose computed tomography (LDCT) reduces mortality from lung cancer. Relatives with family history of lung cancer are at increased risk of lung cancer compared to those without a family history in pooled analysis. A prospective trial using LDCT of lung to screen the relatives with family history of lung cancer is needed.

Investigators invited participants with family history to join in this study under the criteria of (1) relatives of the lung cancer patients; (2) age older than 55 years old or age older than the age of onset of lung cancer proband if the family members were less than 55 years old; (3) compulsory signing the consent agreement after understanding the purpose of study and the exposure of radiation. The participants with (1) proved lung cancer either with or without treatment, (2) presence of hemoptysis or history of remarkable lung fibrosis, (3) any other cancer history or (4) chest CT examination within one year would be excluded from the study.

The study was planned to enroll 1000 participants from simplex families and 500 participants from multiplex families for lung LDCT screening. Multiplex family was defined as two or more family members with lung cancers, and simplex family as one family member with lung cancer.

Low-dose Computed Tomography Screening for Lung Cancer in Relatives With Family History of Lung Cancer

Ministry of Health and Welfare, Taiwan

Taichung Veterans General Hospital

Attending physician

Autoantibodies

Every study participant receives a CT scan \& Early CDT-Lung test (biomarker blood test) for lung cancer screening purposes.

CT scan & Early CDT Lung test

James R Jett, MD

Lung cancer is the number one cancer killer in the USA. Early stage lung cancer is asymptomatic. Most patients with lung cancer are usually symptomatic at diagnosis and already have advanced stage disease. Low dose CT screening (LDCT) for high risk individuals has recently been shown to decrease lung cancer mortality by 20%. However, 4 out of 5 lung cancer deaths are not prevented with LDCT screening alone.

In this trial, the addition of a blood biomarker test is being combined with early LDCT to determine if screening with combination may result in detection of more lung cancer at an earlier stage of disease.The study will also assess if the blood test is able to detect lung cancers in high risk individuals when the LDCT is negative for cancer. There will be health-economic costs included in the final analysis of study data.

Lung Cancer Screening Study With Low-dose CT Scan and Blood Biomarker

Different Strategies Using Autoantibodies and/or CT Scan Detection of Lung Cancer

Comparison of the health economic costs of Early CDT-Lung test and CT scan when each is used individually or in combination.

Assess the number of lung cancers detected with CT alone vs. with both Early CDT-Lung test and CT scan. Compare positive CT results with positive/negative Early CDT Lung test results and assess ability of the combination to detect earlier stage lung cancer.

Assess the value of Early CDT-lung test in detecting lung cancer in individuals who are CT scan negative but positive for Early CDT-lung.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Low-dose Computed Tomography Screening for Lung Cancer in Relatives With Family History of Lung Cancer	NCT02519972	Lung Cancer	low dose comput...	55 Years - 75 Years	Taichung Veterans General Hospital
Lung Cancer Screening Study With Low-dose CT Scan and Blood Biomarker	NCT01700257	High Risk of De...	CT scan & Early... CT scan & Early...	50 Years - 75 Years	National Jewish Health
Lung Cancer Screening Study With Low-dose CT Scan and Blood Biomarker	NCT01700257	High Risk of De...	CT scan & Early... CT scan & Early...	50 Years - 75 Years	National Jewish Health

Spots Global Cancer Trial Database for family history of lung cancer