Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Infertility

Infertility, Female

Genital Diseases

Urogenital Diseases

Genital Diseases, Female

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

The decision aid is then developed further process of evidence synthesis and multidisciplinary external review.

web-based decision aid

Shiu-Yu K Lee, PhD

Wen-Fang Cheng

This study aims to develop a patient-centered, user-center, interactive web-based decision aid to support the young women with cancer in making an informed fertility-related decision and further evaluate its efficacy.

This study uses mixed-method and involves 2 stages. As following the IPDAS recommendation for developing decision aids, the first sample of 25 young woman survivors with breast, hematology or ovarian cancer, and oncologist, fertility specialists or nurses will be interviewed to assess the fertility-related decision needs from and. The decision aid is then developed further process of evidence synthesis and multidisciplinary external review. After the draft being evaluated for its validity via Think-aloud cognitive interview method, field testing via one-group quasi-experimental design on 90 young women with newly diagnosed breast, hematology or ovarian cancer will be applied to test its outcomes of decision quality, emotional health and fertility concerns.

Development and Evaluation of Web-Based Fertility-Related Decision Support for Young Female Cancer Patients

National Taiwan University Hospital

Behaviors and Mental Disorders

Symptoms and General Pathology

Neoplasms

Gland and Hormone Related Diseases

Anxiety Disorders

Depression

Depressive Disorder

Cognitive Dysfunction

Fatigue

Testicular Neoplasms

Cognition Disorders

Neurocognitive Disorders

Mental Disorders

Psychotic Disorders

Endocrine Gland Neoplasms

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases, Male

Male Urogenital Diseases

Endocrine System Diseases

Testicular Diseases

Gonadal Disorders

Quality of Life

This is a prospective observational study, that investigates men diagnosed with testicular cancer before and after treatment.

The patients are included at their visit at the Fertility clinic in Horsens, where they deposit semen for cryopreservation prior to surgery and potential systemic treatment. Here the patients, who want to participate will perform a cognitive test and afterwards complete a questioner (T1). After 9 month the patients will be invited to perform the cognitive test and complete the questionnaire again (T2).

Mental Health of Men Before and After Testicular Cancer Treatment

Mental Health of Men Before and After Testicular Cancer Treatment. Danish: "Mænds Mentale Sundhed før og Efter Behandling af testikulær kræft"

The cognitive test is performed on an iPad using the validated Cambridge Neuropsychological Test Automated Battery (CANTAB) Connect Research software. The cognitive domains assessed are sensorimotor function and comprehension, processing and psychomotor speed, sustained attention, visual episodic memory, working memory and strategy, visual working memory and planning, each at T1 and T2. Comparison of test results from T1 and T2 will assess if there is a change in the cognitive performance.

Assessed by The Patients Assessment of Own Functioning Inventory (PAOFI)

Assessed by the EORTC Sexual Health Questionnaire (EORTC SHQ-C22)

Assessed by The International Index of Erectile Function (IIEF-5)

Assessed by the Hospital Anxiety and Depression Scale (HADS). The HADS is a 14-item scale with 2 subscales measuring severity of anxiety (HADS-A) and depression (HADS-D) symptoms. Each subscale has 7 items and each item is scored from 0-3. Thus, the total score for each subscale range from 0-21, with 0 indicating no symptoms and 21 severe symptoms.

Assessed by the FACIT_Fatigue Questionnaire. The questionnaire consists of 13-items each scored from 0-4. The scores are summarized, and the total score range from 0-52 with higher score denoting less fatigue.

Assessed by the Pittsburgh Sleep Quality Index (PSQI)

The quality of life is assessed by a subscale from the WHO Quality of Life (WHOQOL)-BREF questionnaire. The subscale has 2 questions each scored from 1-5. Thus, the total score for this subscale range from 2-10 with higher scores denoting higher quality of life.

The wellbeing is assessed by the WHO (Five) Well-being scale (WHO-5), that has 5 questions each scored from 0-5. The raw score ranges from 0-25 and is multiplied by 4 to give the final score that ranges from 0-100, with higher scores denoting higher wellbeing.

The patient answers 5 questions regarding fertility related concerns, investigating if he has concerns about being able to become a father with or without fertility assistance. Also, the patient answers 4 questions regarding the information given by healthcare professionals, to assess if he finds, that he has been given enough information regarding semen deposit and possible later fertility assistance.

None of these 9 questions are validated.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Development and Evaluation of Web-Based Fertility-Related Decision Support for Young Female Cancer Patients	NCT03786458	Infertility, Fe... Female Infertil...	web-based decis...	20 Years - 44 Years	National Taiwan University Hospital
Development and Evaluation of Web-Based Fertility-Related Decision Support for Young Female Cancer Patients	NCT03786458	Infertility, Fe... Female Infertil...	web-based decis...	20 Years - 44 Years	National Taiwan University Hospital
Mental Health of Men Before and After Testicular Cancer Treatment	NCT03880994	Testis Cancer Cognitive Impai... Sexual Dysfunct...		18 Years - 45 Years	University of Aarhus

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