Symptoms and General Pathology

All Conditions

Neoplasms

Digestive System Diseases

Inflammation

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Other Dietary Supplements

All Drugs and Chemicals

Omega 3 Fatty Acid

will receive the supplementation of 2 g / day of fish oil encapsulated for 9 weeks

not will receive supplementation or encapsulated fish oil or placebo

fish oil encapsuled

Michel C Mocellin, Master's

The purpose of this study is to evaluate whether supplementation 2g/day encapsulated fish oil modifies inflammatory markers in individuals with colorectal cancer in chemotherapy

The study will recruit patients with newly diagnosed colorectal cancer and that has not yet undergone any chemotherapy treatment. Individuals that meet the inclusion criteria are randomized by means of a computer program on two study groups: 1) supplemented Experimental: receive 2g/day supplementation encapsulated fish oil for 9 weeks. 2) No intervention - control: not receive supplementation of fish oil or placebo. Will be assessed the effects of supplementation on the standard profile of cytokine production, nutritional status, and proportion of incorporation of these fatty acids in blood cells (mononuclear and red blood cells).

Blood samples are collected before the start of first chemotherapy and nine weeks later. Supplementation in the experimental group also will start on the first day of chemotherapy.

Study to Assess the Effect of Consumption of Fish Oil Encapsulated on Inflammatory Markers in Colorectal Cancer

Markers of the Inflammatory Response (IL-1β, IL-10, IL-17A and TNF-α) in Patients With Colorectal Cancer in Chemotherapy Supplemented With Fish Oil

will be evaluated cytokines IL-1 beta, IL-10, IL-17A and TNF alpha, and acute phase proteins CRP and Albumin, in baseline that corresponds to the day that the patient will begin chemotherapy and the final moment, which corresponds to 9 weeks counting from the baseline in both groups (supplemented and non-supplemented)

will estimate the percentage of body fat in each patient through the use of skinfold thickness at baseline and end to study in both groups

will be measured anthropometric measures: weight and height (baseline and end of study) for the classification of nutritional status according to BMI

will evaluate the proportion of incorporation of omega-3 fatty acids in plasma

Will be calculated the ratio PCR / albumin, as proposed by Correa et al., 2002, using the cutoff points proposed by the same author for the classification of high, medium, decreased or no risk

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Study to Assess the Effect of Consumption of Fish Oil Encapsulated on Inflammatory Markers in Colorectal Cancer	NCT01575340	Colorectal Canc... Inflammation	fish oil encaps...	19 Years -	Universidade Federal de Santa Catarina
Study to Assess the Effect of Consumption of Fish Oil Encapsulated on Inflammatory Markers in Colorectal Cancer	NCT01575340	Colorectal Canc... Inflammation	fish oil encaps...	19 Years -	Universidade Federal de Santa Catarina
Study to Assess the Effect of Consumption of Fish Oil Encapsulated on Inflammatory Markers in Colorectal Cancer	NCT01575340	Colorectal Canc... Inflammation	fish oil encaps...	19 Years -	Universidade Federal de Santa Catarina

Spots Global Cancer Trial Database for fish oil encapsuled