Neoplasms

Digestive System Diseases

All Conditions

Behaviors and Mental Disorders

Symptoms and General Pathology

Colorectal Neoplasms

Depression

Colonic Polyps

Polyps

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Pathological Conditions, Anatomical

Intestinal Polyps

Use of high definition narrow band imaging colonoscopy during examination for polyp detection. The same intervention is used on both arms: the Olympus Colonoscope CFHQ190AL, a technically improved colonoscope with close focus high definition narrow band imaging.

Use of high definition white light colonoscopy during examination for polyp detection. The same intervention is used on both arms: the Olympus Colonoscope CFHQ190AL, a technically improved colonoscope with close focus high definition narrow band imaging.

Technically improved colonoscope with close focus high definition narrow band imaging.

Olympus Colonoscope CFHQ190AL

Tonya Kaltenbach, MD MS

We hypothesize that high definition narrow band imaging (NBI) colonoscopy compared to high definition white light colonoscopy will detect an increased number of nonpolypoid (flat and depressed) colorectal neoplasm.

Interval colorectal cancers diagnosed within a three year period following a clearing colonoscopy have been reported at a rate of 1 cancer/1000 person years.The majority of these cancers are likely a consequence of a missed neoplastic lesion during routine colonoscopy. Recent tandem colonoscopy studies have shown no significant difference in adenoma miss or detection rates using narrow band imaging as compared to colonoscopy using white light. However, higher detection of flat neoplastic lesions using NBI was shown in a meta-analysis and should be furthered studied, especially considering that they are thought to be a strong contributor to a false negative colonoscopy.

Study of Flat Polyp Detection Using New Narrow Band Imaging (NBI) Compared to White Light Colonoscopy - The FIND FLAT Colonoscopy Study

Full Inspection With Narrow Band Imaging (NBI) for Detection of Flat Lesions And Tumors During Colonoscopy- The FIND FLAT Colonoscopy Study

Compare the nonpolypoid colorectal neoplasm detection characteristics of the new high definition narrow band imaging colonoscopy to conventional high definition white light mode colonoscopy.

Compare the number of missed lesions on the index examination using the new high definition narrow band imaging colonoscopy to the conventional high definition white light mode colonoscopy, based on the tandem colonoscopy findings.

Compare the number of missed non-polypoid lesions on the index examination using the new high definition narrow band imaging colonoscopy to the conventional high definition white light mode colonoscopy.

Kansas City Veteran Affairs Medical Center

VA Palo Alto Health Care System

Co-Principal Investigator

Use of high definition narrow band imaging colonoscopy during examination for polyp detection.

Olympus Colonoscope CFHQ190AL: Technically improved colonoscope with close focus high definition narrow band imaging.

High Definition NBI Colonoscopy

Use of high definition white light colonoscopy during examination for polyp detection.

Olympus Colonoscope CFHQ190AL: Technically improved colonoscope with close focus high definition narrow band imaging.

High Definition White Light Colonoscopy

Total

Age, Continuous

Sex: Female, Male

Dr. Tonya Kaltenbach

Number of Participants With Nonpolypoid (Flat and Depressed) Colorectal Neoplasm

Use of high definition narrow band imaging colonoscopy during examination for polyp detection. The same intervention is used on both arms: the Olympus Colonoscope CFHQ190AL, a technically improved colonoscope with close focus high definition narrow band imaging.

Olympus Colonoscope CFHQ190AL: Technically improved colonoscope with close focus high definition narrow band imaging.

Use of high definition white light colonoscopy during examination for polyp detection. The same intervention is used on both arms: the Olympus Colonoscope CFHQ190AL, a technically improved colonoscope with close focus high definition narrow band imaging.

Olympus Colonoscope CFHQ190AL: Technically improved colonoscope with close focus high definition narrow band imaging.

Spots Global Cancer Trial Database for flat and depressed lesions