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Breast Neoplasms

Breast Diseases

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intradermal injection of 2.5 milligrams of indocyanine green and 20 MBq of technetium 99 before breast surgery

intradermal injection of 20 MBq of technetium 99 before breast surgery

One injection, 2.5 milligrams per patient, intradermal use

indocyanine green

One injection, 20 MBq techntium99, intradermal use

isotope

Céline CHAULEUR, PhD

The sentinel node has a fundamental role in the management of early breast cancer.

Currently, the double detection of blue and radioisotope is recommended. A radioactive material requires the presence of a nuclear medicine department and the approval of health authorities. In many centers, this technique is not available. The use of blue is easier to implement technique. However, allergic reactions and prolonged breast tattoo led many teams to stop the practice.

So in common practice, many center use a single method. However, with a single detection, the risk of false negatives and the identification failure rate increased to a significant extent and the number of sentinel lymph node detected and removed is not enough.

Under these conditions, find another method of detection seems crucial. According to the literature, the fluorescence method (ICG) is a technique that seems safe and reliable.

The investigators therefore propose a prospective, randomized study to investigate the interest of fluorescence associated with the isotopic method.

Study Assessing The Interest of Indocyanine Green Fluorescence Imaging With Radioisotope Method For Sentinel Lymph Node Biopsy in Patients With Breast Cancer

Comparative, Prospective, Randomized Study Assessing The Interest of Indocyanine Green Fluorescence Imaging With Radioisotope Method For Sentinel Lymph Node Biopsy in Patients With Breast Cancer

Number of patients with less than two lymph nodes detected by indocyanine (ICG) + isotope versus isotope detection alone

Number of lymph nodes Indocyanine green (ICG) positive and Tc (Technetium)positive

Number of lymph nodes Indocyanine green (ICG) positive and Tc (Technetium) negative

Number of lymph nodes Indocyanine green (ICG) negative and Tc (Technetium) positive

time from the injection of anesthesic to the waking

time from injection of one dose ICG injection to incision time

time from incision time to the last node surgery

allergy is : redness, edema, itching, larynges edema and/or allergic shock

Centre Hospitalier Universitaire de Saint Etienne

intradermal injection of 2.5 milligrams of indocyanine green and 20 MBq of technetium 99 before breast surgery

indocyanine green: One injection, 2.5 milligrams per patient, intradermal use

isotope: One injection, 20 MBq techntium99, intradermal use

Double Detection Indocyanine + Isotope

intradermal injection of 20 MBq of technetium 99 before breast surgery

isotope: One injection, 20 MBq techntium99, intradermal use

Isotope Detection Alone

Total

Age, Continuous

Sex: Female, Male

Race and Ethnicity were not collected from any participant.

Spots Global Cancer Trial Database for fluorescence method