Gland and Hormone Related Diseases

All Conditions

Neoplasms

Behaviors and Mental Disorders

Thyroid Diseases

Thyroid Nodule

Endocrine System Diseases

Thyroid Neoplasms

Endocrine Gland Neoplasms

Head and Neck Neoplasms

Quality of Life

patients will then be randomized routine FNAC strategy

patients will be randomized to watchful observation strategy (no FNAC)

Fine Needle Aspiration Cytology

Ideally randomized controlled trials should be carried out to compare the cost-effectiveness between FNAC and watchful waiting but such studies are very difficult to conduct in practice because they require following up very large number of subjects for a long period of time.

The aims are to determine the health-related quality of life (HRQOL) and HRQOL preference (utility) of patients undergoing watchful observation (no FNAC) and routine FNAC, and to determine the cost-effectiveness of two strategies in managing small incidental thyroid nodules for the Chinese population in Hong Kong.

Study on HRQOL and Cost-effectiveness Analysis in Management of Patients With <2cm Thyroid Nodules

A Prospective Randomized Study on Health-related Quality of Life of Patients With Incidental Small (<2cm) Asymptomatic Thyroid Nodules and Cost-effectiveness Analysis in Managing Small Incidental Thyroid Nodules

Health-related Quality of Life (HRQoL) preference value measured by The Chinese (HK) SF-6D Health Survey will be calculated by the Hong Kong population specific algorithm. It ranges from 0 (dead) to 1 (perfect health)

The effectiveness of managing small incidental thyroid nodules is quantified by quality-adjusted life years (QALYs), which will be calculated as the product of average duration of each stage (including no illness) and the SF-6D preference value for that particular health state.

The direct health care costs of different strategies in managing small incidental thyroid nodules will be estimated using the costs published by the Government Gazette and previous literatures.

HRQOL measured by the Chinese (Hong Kong) Short Form-12 (SF-12) Health Survey version 2 and FACT-G will be evaluated to identify these major problem of life.

Health service utilizations of patients with thyroid neoplasm will be surveyed.

Treatment effect on the HRQOL of patients with thyroid carcinoma will be explored.

The University of Hong Kong

Associate Professor

Comparison between FNAC and post operative specimen after thyroid surgery

Amr M Makky, specialist surgical onclogy

Abdullah Atyah Ali, Ass.Lecture General Surgery

Mohamed Ahmed Orabi, specialist surgical onclogy

Mina Romany Tawfeek

Mahmoud Ahmed Dosoky, specialist pathology

Thyroid gland diseases are the second most common endocrine disease following diabetes mellitus(1). Thyroid nodules are common disorders with a prevalence ranged from 4 to 7% in adult population, 5%-30% are malignant \[1\].Fine-needle aspiration cytology (FNAC) is an easy, cost-effective test for cancer diagnosis, and its use has markedly decreased the number of unnecessary thyroid surgeries(2).

it should be noted that FNAC cannot differentiate between benign and malignant follicular neoplasms.differentiation between follicular adenoma and follicular carcinoma is only possible after thyroid lobectomy.\[2,3\] In addition, a study of FNAC showed that 68% of the cases diagnosed by FNAC as follicular neoplasm turned out to be the follicular type of papillary carcinoma, indicting a considerable overlap between benign and malignant neoplasms.\[4\] Incidental findings of thyroid nodules have increased exponen¬tially in recent years, mostly due to the widespread application of high-resolution ultrasound (US) to the thyroid \[5\].Several in¬ternational scientific societies have established clinic-radiolog¬ical guidelines for the diagnosis and the management of thy¬roid nodules \[2,3\]. The American College of Radiology identifies 5 radiological risk levels and recommends US-guided fine-nee¬dle aspiration cytology (US-FNAC) of high-suspicion nodules if 10 mm or larger, and of nodules with a low risk for malignan¬cy only if larger than 25 mm \[2\]. According to the European Thyroid Association Guidelines (EU-TIRADS), nodules with no high-risk features (oval-shaped, isoechoic/hyperechoic with smooth margins) should be considered at low risk and FNA performed only if greater than 20 mm, while high-risk nodules greater than 10 mm should undergo FNAC, with possible FNAC also in 5-10 mm nodules if highly suspicious \[3\].

Accuracy of FNAC in Thyroid Nodules Compared to to Surgical Specimen : QOC Experience

Accuracy of FNAC in thyroid nodules compared to to surgical specimen : QOC experience

type of thyroid malignancy not observed by FNAC

false negative that diagnosed by FNAC not malignant but proved malignancy after surgical excion

Qena Oncology Center

specialist of surgical oncology at Qena Oncology Center

Thyroid nodules are a common presentation in the clinic, with an increasing incidence, especially in women. Their clinical significance is mainly related to excluding malignancy (4.0 to 6.5% of all thyroid nodules).

Thyroid nodule is a discrete lesion in the thyroid gland that is radiologically distinct from the surrounding thyroid parenchyma.

Thyroid nodules are a common presentation in the clinic, with an increasing incidence, especially in women. The detection rate among healthy individuals is as high as 50%-60%, but the reported incidence of malignant nodules in all thyroid nodules has ranged from only 1.6%-12%.

They are discovered either clinically on self-palpation by a patient, or during a physical examination by the clinician or incidentally during a radiologic procedure such as ultrasonography (US) imaging, computed tomography (CT) or magnetic resonance imaging (MRI) of the neck; with the increased use of sensitive imaging techniques, thyroid nodules are being diagnosed incidentally with increasing frequency in the recent years.

Though thyroid nodules are common, their clinical significance is mainly related to excluding malignancy (4.0 to 6.5% of all thyroid nodules), evaluating their functional status and if they cause pressure symptoms.

Thyroid nodules can be caused by many disorders:

Benign (colloid nodule, Hashimoto's thyroiditis, simple or hemorrhagic cyst, follicular adenoma and subacute thyroiditis) and malignant (Papillary Cancer, Follicular Cancer, Hurthle Cell Cancer, Anaplastic Cancer, Medullary Cancer, Thyroid Lymphoma and metastases).

Initial assessment of a patient found to have a thyroid nodule either clinically or incidentally should include a detailed and relevant history plus physical examination. Laboratory tests should begin with measurement of serum thyroid-stimulating hormone (TSH). Thyroid scintigraphy/radionuclide thyroid scan should be performed in patients presenting with a low serum TSH.

Thyroid ultrasound should be performed in all those suspected or known to have a nodule to confirm the presence of a nodule, evaluate for additional nodules and cervical lymph nodes and assess for suspicious sonographic features.

The next step in the evaluation of a thyroid nodule is a fine needle aspiration (FNA) biopsy, which is the gold standard diagnostic test.

Clinical Diagnostic Approach for Cases of Thyroid Nodules

Clinical Diagnostic Evaluation of Thyroid Nodules

develop a rational, cost-effective approach to ordering and interpreting imaging and diagnostic tests in the evaluation of the thyroid nodule.

Assiut University

Assistant Lecturer

Hematinics

All Drugs and Chemicals

Gastrointestinal Agents

Liver Extracts

Pancrelipase

Pancreatin

patients with tumors in liver and/or pancreas

FNAC (fine needle aspiration cytology)

Jakob Burcharth, MD

Bjørn Skjoldbye, MD

Patients with tumors in liver or pancreas are randomized to ultrasound (UL)-guided FNAC biopsies with guidance method or UL-guided FNAC biopsies with free-hand method.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Study on HRQOL and Cost-effectiveness Analysis in Management of Patients With <2cm Thyroid Nodules	NCT02398721	Thyroid Nodules	Fine Needle Asp...	18 Years -	The University of Hong Kong
Accuracy of FNAC in Thyroid Nodules Compared to to Surgical Specimen : QOC Experience	NCT05521594	Fine Needle Asp... Thyroid Disease...	Fine Needle Asp...	15 Years - 80 Years	Qena Oncology Center
Clinical Diagnostic Approach for Cases of Thyroid Nodules	NCT03884140	Thyroid Nodule		18 Years - 75 Years	Assiut University
Ultra Sound Guided Fine Needle Aspiration Cytology (FNAC) of Liver and Pancreas Tumours	NCT00991601	Tumors in Liver Tumors in Pancr...	FNAC (fine need...	18 Years -	Herlev Hospital
Ultra Sound Guided Fine Needle Aspiration Cytology (FNAC) of Liver and Pancreas Tumours	NCT00991601	Tumors in Liver Tumors in Pancr...	FNAC (fine need...	18 Years -	Herlev Hospital
Clinical Diagnostic Approach for Cases of Thyroid Nodules	NCT03884140	Thyroid Nodule		18 Years - 75 Years	Assiut University
Clinical Diagnostic Approach for Cases of Thyroid Nodules	NCT03884140	Thyroid Nodule		18 Years - 75 Years	Assiut University

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Spots Global Cancer Trial Database for fnac

Every month we try and update this database with for fnac cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for fnac cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.