Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Breast Neoplasms

Breast Diseases

Skin Diseases

Breast cancer patients 65 and older undergoing chemotherapy and participating in a home-based physical activity intervention.

The Walk With Ease Program sets a goal for participants to walk 30 minutes a day five times a week and gives helpful hints on how to achieve this goal.

Walk with Ease Program

Hyman Muss, MD

To determine if exercise will affect the increase in p16 expression that is associated with both chemotherapy administration and advancing age.

LCCC1410 is designed to compare the change in p16 from baseline to end of chemotherapy in 100 older (≥ 65 years) breast cancer patients participating in a home-based physical activity program (intervention group) to 100 patients in the concurrent control group not participating in a physical activity intervention (enrolled in a separate RO1 study as described in section 1.7). The biomarker p16 is known to dramatically increase with chemotherapy, and we hypothesize that the increase will be attenuated by a physical activity intervention. We will evaluate changes in p16 between the two study populations. Data from the geriatric assessment at baseline will be used to characterize the study population, and subscale scores from the GA will also be assessed for differences between baseline and end of chemotherapy to compare the LCCC1410 study population with the concurrent control.

Impact of Physical Activity on Biomarker of Aging and Body Composition Among Breast Cancer Survivors Age 65 and Older

LCCC 1410: Impact of Physical Activity on Biomarker of Aging and Body Composition Among Breast Cancer Survivors Age 65 and Older

The comparison group will be taken from another study

The study will look at the change of p16 expression within patients on this study.

As measured by engagement in walking survey

As measured by the Short Physical Performance Battery

• Retention will be assessed as the proportion of patients who enroll in the study who complete all questionnaires and assessments at all time points.

• Safety will be defined as any adverse events potentially related to the intervention, including falls, which are reported by study participants to the Study Team.

As measured by a satisfaction questionnaire

As measure via an continuous accelerometer.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Impact of Physical Activity on Biomarker of Aging and Body Composition Among Breast Cancer Survivors Age 65 and Older	NCT02328313	Breast Cancer Aging Physical Activi...	Walk with Ease ...	65 Years -	UNC Lineberger Comprehensive Cancer Center
Impact of Physical Activity on Biomarker of Aging and Body Composition Among Breast Cancer Survivors Age 65 and Older	NCT02328313	Breast Cancer Aging Physical Activi...	Walk with Ease ...	65 Years -	UNC Lineberger Comprehensive Cancer Center

Spots Global Cancer Trial Database for genetic marker