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Gastrointestinal Agents

Hormones

Glucagon

Glucagon-Like Peptide 1

Hormone Antagonists

John Cello, MD

The investigators believe that glucagon therapy will have a positive impact on key parameters of colonoscopy such as cecal intubation time, withdrawal time, total procedure time, adenoma detection rate, endoscopist's assessment of the difficulty of the procedure, patient comfort, and patient's willingness to undergo a repeat colonoscopy.

Glucagon transiently decreases peristalsis of smooth muscle in the gastrointestinal tract. It is widely used by radiologists to improve diagnostic yields of upper and lower GI barium contrast examinations. Glucagon is also routinely administered intravenously for all endoscopic retrograde cholangiopancreatography (ERCP) throughout the United States to facilitate canulation of the duodenal papilla and sphincterotomy. Glucagon has been used at the dose of 1-3 mg intravenously by Dr. John Cello in over 5000 ERCP examinations. The role of glucagon in facilitating colonoscopy remains controversial however and is not considered "routine". Several studies have evaluated the effect of glucagon on colonoscopy with varying results. No large scale randomized controlled trial has been performed to conclusively establish the effect of routine glucagon administration prior to colonoscopy. The investigators plan to carry out a randomized double blind, placebo controlled trial that studies key parameters of a colonoscopy such as cecal intubation time, withdrawal time, total procedure time, adenoma detection rate, endoscopist's assessment of the difficulty of the procedure, patient comfort, and patient's willingness to undergo a repeat colonoscopy.

Glucagon Use in Colonoscopies

Role of Glucagon in Outpatient Colonoscopy? A Prospective Double-Blind Randomized Controlled Trial

ADR was defined as the percentage of participants with at least one traditional adenoma (including tubular or villous adenomas, and adenomas with high grade dysplasia or adenocarcinoma) of any size.

University of California, San Francisco

1 mg glucagon given during colonoscopy

Glucagon: glucagon (hormone produced by the body)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Glucagon Use in Colonoscopies	NCT02078726	Colon Cancer	Glucagon	18 Years - 70 Years	University of California, San Francisco
Glucagon Use in Colonoscopies	NCT02078726	Colon Cancer	Glucagon	18 Years - 70 Years	University of California, San Francisco
Glucagon Use in Colonoscopies	NCT02078726	Colon Cancer	Glucagon	18 Years - 70 Years	University of California, San Francisco

Spots Global Cancer Trial Database for glucagon, screening colonoscopy