Symptoms and General Pathology

All Conditions

Skin and Connective Tissue Diseases

Neoplasms

Blood and Lymph Conditions

Diseases and Abnormalities at or Before Birth

Musculoskeletal Diseases

Immune System Diseases

Rare Diseases

Hypertrophy

Cicatrix, Hypertrophic

Cicatrix

Psoriasis

Eczema

Keloid

Pain

Lichen Planus

Prurigo

Acne Vulgaris

Scleroderma, Localized

Neurodermatitis

Alopecia

Alopecia Areata

Cysts

Granuloma

Granuloma Annulare

Epidermal Cyst

Keratoacanthoma

Muir-Torre Syndrome

Skin Diseases

Skin Diseases, Papulosquamous

Hypotrichosis

Hair Diseases

Pathological Conditions, Anatomical

Dermatitis

Skin Diseases, Eczematous

Lichenoid Eruptions

Exanthema

Rheumatic Diseases

Collagen Diseases

Connective Tissue Diseases

Fibrosis

Lymphoproliferative Disorders

Lymphatic Diseases

Necrobiotic Disorders

Prurigo Nodularis

Lichen Planopilaris

Frontal Fibrosing Alopecia

Morphea

Localized Scleroderma

Anti-Arrhythmia Agents

Channel Blockers

Central Nervous System Depressants

All Drugs and Chemicals

Lidocaine

Anesthetics

Anesthetics, Local

Sodium Channel Blockers

Diuretics, Potassium Sparing

This arm will include an injection mixture of corticosteroid and lidocaine

This arm will include a mixture of corticosteroid and normal saline. The purpose of normal saline is to keep the volume and concentration similar when compared to the injections containing lidocaine.

Corticosteroid with lidocaine

Corticosteroid with normal saline

Brian Drolet, MD

Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics. However, these injections can be quite painful, which leads many patients to discontinue treatment.

Often, the injection involves a mixture of local anesthetic and corticosteroids despite a lack of evidence that the use of lidocaine improves pain. Due to the acidic pH, the lidocaine component of the injection can actually cause a significant burning sensation during the procedure. Lidocaine does not have anti-inflammatory properties and does not treat the underlying pathology. By including another medication, lidocaine also adds cost and risk to the procedure.

The purpose of this study is to see if removing lidocaine from intralesional injections decreases the pain of injection.

Pain Outcomes Following Intralesional Corticosteroid Injections

The Use of Local Anesthetic in Intralesional Corticosteroid Injections; A Randomized, Double Blind Controlled Trial

IPD will not be shared with other researchers

Assessed using the visual analog scale (0-10 scale). Zero indicates no pain, 10 indicates worst pain ever.

Vanderbilt University Medical Center

Assistant Professor

This arm will include an injection mixture of corticosteroid and lidocaine

Corticosteroid with lidocaine: Intralesional corticosteroid injection

Corticosteroid With Lidocaine

This arm will include a mixture of corticosteroid and normal saline. The purpose of normal saline is to keep the volume and concentration similar when compared to the injections containing lidocaine.

Corticosteroid with normal saline: Intralesional corticosteroid injection

Spots Global Cancer Trial Database for granuloma annulare