Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

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Symptoms and General Pathology

Lung Neoplasms

Disease Susceptibility

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

All the patients with proved malignant ground glass nodule will be enrolled.

Jia-Tao Zhang, Ph.D

Rui Fu, MD

Jia-Tao Zhang

Wen-Zhao Zhong

Wenzhao Zhong, Ph。D

The aim of the present prospective cohort study (GGN-F) is to study the family aggregation of pulmonary ground glass nodules via the questionnaire survey and to investigate the underlying genetic mechanism via the biobank.

In recent years, with the development of low-dose chest CT screening, more and more ground glass nodules have been found. Meanwhile, presenting as Ground-glass nodule (GGN), the early-stage lung adenocarcinoma patients with lung cancer family history have been emerging increasing in recent years in East Asian.

This prospective cohort study, with both a cross-sectional and a longitudinal part, will include patients with pulmonary ground glass nodule, which were proven malignant disease.

All participants will be asked to complete questionnaire to build the clinical database of GGN patients with detailed family history. Furthermore, blood and surgical tumor samples will be collected as a specific biobank. And the blood samples of other family members of participants will be collected, with their consent and knowledge.

Blood and surgical tumor samples of all the participants will be collected. Moreover, blood samples of other family members of participants will be collected, with their consent and knowledge.

A Prospective Cohort of Pulmonary Ground Glass Nodules Patients With Family History.

Clinical Database and Biobank of Pulmonary Ground Glass Nodules Patients With Family History, a Prospective Cohort Study.

To investigate the aggregation of pulmonary ground glass nodule among first-degree relatives of participants via the questionnaire.

To investigate the underlying susceptibility genetic loci which concern with familial inheritance of ground glass nodule.

Guangdong Provincial People's Hospital

Porfessor

Rare Diseases

Adenocarcinoma

Adenocarcinoma of Lung

Carcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Lung Adenocarcinoma

Herbal and Botanical

All Drugs and Chemicals

Ginseng

Chinese Rhubarb

The patients in the trial group received routine Western medicine treatments, and oral Lifei Xiaoji Wan (10 pills/time,3 times/day).

The patients in the control group received routine Western medicine treatments.

The Lifei Xiaoji Wan consists of ginseng, blackhead,rhubarb, aster, forehu, and thin on.

Lifei Xiaoji Wan

Recommended treatment protocols for patients with Stage Ia NSCLC in the "Chinese Society of Oncology Branch of Lung Cancer Clinical Diagnosis and Treatment Guidelines for Lung Cancer (2021 edition)" and the "Chinese Society of Clinical Oncology (CSCO) Non-small Cell Lung Cancer Diagnosis and Treatment Guidelines 2021".

Conventional treatment with Western medicine

Mingli Zhao, MD

This study evaluated the relationship between the clinical efficacy, histopathological changes and tumor microenvironment of the pharmacopharmacologic Lifei Xiaoji Wan in the treatment of early stage lung adenocarcinoma, and improved high-level clinical evidence and action targets for the prevention and treatment of early stage lung cancer by traditional Chinese medicine

Lung cancer is a malignant tumor with the highest morbidity and mortality. The microenvironment of tumor plays an important role in its occurrence and development.Traditional Chinese medicine has great advantages in the prevention and treatment of ground glass pulmonary nodules, but there is a lack of high-level clinical evaluation evidence and precise mechanism of action.Lifei Xiaoji Wan is a prescription based on the theory of "gas accumulation causing cancer". It has good curative effect in treating non-small cell lung cancer.

In this study, a single-center randomized controlled study was used to set up a treatment group and a control group to observe and evaluate the clinical efficacy of Lifeixiaoji pills on patients with early stage lung adenocarcinoma of ground glass nodules. Flow cytometry, PCR array and multiple fluorescence immunofluorescence were used to detect the tumor microenvironment in lung cancer tissues. To investigate the effect of Lifeixiaoji pill on tumor microenvironment and its mechanism of action on early lung adenocarcinoma.

Lifei Xiaoji Wan Treatment's of Early-stage NSCLC and Its Impact on the Tumor Microenvironment

Study on the Therapeutic Effect of Lifei Xiaoji Wan on Lung Adenocarcinoma in the Early Stage of Ground Glass Nodule (Ia Stage) and Its Effect on Tumor Microenvironment

FACT-L scale was used to record the patients' physiological status, social/family status, emotional status and functional status

The evaluation was carried out according to the standard of TCM syndrome of lung cancer in Guiding Principles for Clinical Research of New Chinese Medicine

The changes of tumor body and lesion were observed and the therapeutic effect on tumor was evaluated

Tumor marker squamous cell carcinoma antigen levels.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
A Prospective Cohort of Pulmonary Ground Glass Nodules Patients With Family History.	NCT04220268	Lung Neoplasms Family Research		-	Guangdong Provincial People's Hospital
A Prospective Cohort of Pulmonary Ground Glass Nodules Patients With Family History.	NCT04220268	Lung Neoplasms Family Research		-	Guangdong Provincial People's Hospital
Lifei Xiaoji Wan Treatment's of Early-stage NSCLC and Its Impact on the Tumor Microenvironment	NCT06387134	Early Stage Lun...	Lifei Xiaoji Wa... Conventional tr...	18 Years - 75 Years	Henan University of Traditional Chinese Medicine

Spots Global Cancer Trial Database for ground glass nodule