Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Symptoms and General Pathology

Rare Diseases

Lung Neoplasms

Lung Diseases

Lung Diseases, Obstructive

Pulmonary Disease, Chronic Obstructive

Pulmonary Emphysema

Emphysema

Respiratory Tract Neoplasms

Thoracic Neoplasms

Respiratory Tract Diseases

Chronic Disease

Disease Attributes

Chronic Graft Versus Host Disease

Micronutrients

All Drugs and Chemicals

Mineral

Iron

Zinc

Copper

Vanadium

Nickel

Copper Supplement

Lung surgery

Stanislas Grassin Delyle

Prospective research to study the relationship between concentrations of metals/metalloids in blood, hair and lung tissue with the occurence of lung cancer or chronic obstructive pulmonary disease.

Blood, Hair and Lung Concentrations of Metals and Metalloids in Patients With Lung Cancer or Chronic Obstructive Pulmonary Disease

Relationship Between Blood, Hair and Lung Metals/Metalloids Concentration (Cadmium, Iron, Copper, Nickel, Chrome, Arsenic, Vanadium, Beryllium, and Zinc) and Lung Cancer or Chronic Obstructive Pulmonary Disease.

Hopital Foch

Skin and Connective Tissue Diseases

Breast Neoplasms

Breast Diseases

Skin Diseases

x-ray diffraction of human hair

Peter French, BSc, MSc, PhD

Gary Corino, BSc

Phillip Yuile, MBBS (Hons), FRNZCR

Study FT3.6k-2006 is a single centre (the Mater Hospital, Sydney), blinded trial of a diagnostic test for breast cancer, with outcomes compared to the gold standard of screening mammogram followed by biopsy where required. This study aims to perform X-ray diffraction analysis of coded hair samples from women with a documented breast health status, to validate the findings of James et al (Nature 398: 33-4, 1999; Int J Cancer 114: 969-72, 2005) who showed that the presence of breast cancer could be detected using synchrotron-derived x-ray diffraction of human hair (scalp or pubic). The aim is also to characterise the sensitivity and specificity of the hair test in detecting breast cancer in a screening setting, and to determine the significance of a positive hair test and a negative mammogram.

The test has the potential to improve the diagnostic (and consequently therapeutic) paradigm for breast cancer.

Women attending a radiology clinic in the Mater Hospital, Sydney, for a mammogram will be invited to participate in the study. A few hairs will be cut from their head or pubic region, put into a coded container and sent to the sponsor for analysis by synchrotron-x-ray diffraction. Although an imperfect standard for a variety of reasons, mammography is the standard screening assay, and confirmation of the pathology of the lesions found by mammography is carried out by biopsy. This will be the standard to which the hair test results will be compared. A negative mammogram will confirm a negative hair test, but a negative mammogram combined with a positive hair diffraction test will need a different approach. In the event of a positive hair test and a negative second read of the mammogram, the patient will be contacted by the referring practitioner. Patients in this category will be offered a breast MRI. A negative breast MRI under these circumstances will be classified as a true negative.

Use of Hair to Diagnose Breast Cancer

A Prospective Blinded Study to Evaluate and Characterise an Assay for the Diagnosis of Breast Cancer Using Synchrotron-Derived X-Ray Diffraction of Hair Fibres.

Fermiscan Ltd

Cutting scalp hair

Peter W French, BSc, MSc, PhD

Ronald Shnier, MBBS, FRACR

This study aims to perform x-ray diffraction analysis of blinded hair samples from women with a documented health status, to validate the previous findings of James et al who described that x-ray diffraction patterns of human hair can distinguish samples from healthy subjects from those of diseased subjects, specifically those suffering from breast cancer.

The primary hypothesis is that x-ray diffraction of hair can be used to distinguish hair from patients with confirmed breast cancer from subjects without detectable breast cancer.

A Study to Evaluate a Test for the Diagnosis of Breast Cancer Using X-Ray Diffraction of Hair Fibres.

Alopecia

Alopecia Areata

Hypotrichosis

Hair Diseases

Pathological Conditions, Anatomical

Pharmaceutical Solutions

Herbal Medicinal Product, topical use by spray on the scalp

Placebo, topical use by spray on the scalp

The patient will spray treatment 10 times directly to the scalp area, with the cannula, and then gently massage the whole scalp with fingertips, twice a day, spaced out by minimum 4 hours

CG 428 cutaneous solution

Placebo cutaneous solution

Khalil KZ ZAMAN

The aim of this trial is to compare the degree of efficacy, safety and tolerability of CG 428 cutaneous solution versus placebo on prevention of chemotherapy induced alopecia (CIA) in female patients with metastatic cancer treated with selected regimens inducing alopecia.

Efficacy, Safety and Tolerability of CG428 Cutaneous Solution on Chemotherapy Induced Alopecia; Controlled Study (ELAN)

A Randomized, Double Blind, Single Center, Controlled Study to Compare the Efficacy, Safety and Tolerability of CG 428 Cutaneous Solution With Placebo on Alopecia in Cancer Female Patients Under Chemotherapy

Physical examination of the scalp: skin AEs, hair status (alopecia graded according to CTCAE v.4.03.)

CTCAE v. 4.03 : Common Toxicity Criteria for Adverse Event (skin toxicity)

Olsen's visual analog scale : visual aid for estimating percentage scalp hair loss.

Legacy Healthcare SA

diagnosis of breast cancer by x-ray diffraction of hair

Phillip Yuile, MBBS, FRACR

Using synchrotron X-ray diffraction, it has been reported that a hair from an individual with breast cancer exhibits a difference in its molecular structure compared to that of an individual without breast cancer. This difference is visible in the X-ray diffraction pattern as a ring superimposed on the pattern for normal hair.

The hypothesis of this study is that synchrotron x-ray diffraction can be used to differentiate hairs from women with medically diagnosed breast cancer from women not known to have the disease.

To test this hypothesis, hair from 2000 women attending radiology clinics for mammography will be collected, analysed by x-ray diffraction and then analysed using Fermiscan proprietary image analysis software. The mammogram status of the subjects will be blinded from the diffraction analysts. Results will then be compared with mammography results to allow a direct comparison between the Fermiscan test and mammography in terms of specificity and sensitivity.

Use of Hair to Diagnose the Presence of Breast Cancer

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Blood, Hair and Lung Concentrations of Metals and Metalloids in Patients With Lung Cancer or Chronic Obstructive Pulmonary Disease	NCT01949181	Lung Cancer Chronic Obstruc... Emphysema Lung Surgery	Lung surgery	18 Years - 75 Years	Hopital Foch
Use of Hair to Diagnose Breast Cancer	NCT00419679	Breast Neoplasm...	x-ray diffracti...	20 Years -	Fermiscan Ltd
Use of Hair to Diagnose Breast Cancer	NCT00390377	Breast Cancer	Cutting scalp h...	20 Years -	Fermiscan Ltd
Efficacy, Safety and Tolerability of CG428 Cutaneous Solution on Chemotherapy Induced Alopecia; Controlled Study (ELAN)	NCT02919735	Alopecia	CG 428 cutaneou... Placebo cutaneo...	18 Years -	Legacy Healthcare SA
Efficacy, Safety and Tolerability of CG428 Cutaneous Solution on Chemotherapy Induced Alopecia; Controlled Study (ELAN)	NCT02919735	Alopecia	CG 428 cutaneou... Placebo cutaneo...	18 Years -	Legacy Healthcare SA
Use of Hair to Diagnose the Presence of Breast Cancer	NCT00419900	Breast Cancer	diagnosis of br...	20 Years -	Fermiscan Ltd
Blood, Hair and Lung Concentrations of Metals and Metalloids in Patients With Lung Cancer or Chronic Obstructive Pulmonary Disease	NCT01949181	Lung Cancer Chronic Obstruc... Emphysema Lung Surgery	Lung surgery	18 Years - 75 Years	Hopital Foch

Spots Global Cancer Trial Database for hair

Every month we try and update this database with for hair cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for hair

Every month we try and update this database with for hair cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for hair cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.