Nutritional and Metabolic Diseases

Gland and Hormone Related Diseases

All Conditions

Symptoms and General Pathology

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Diabetes Mellitus

Syndrome

Polycystic Ovary Syndrome

Insulin Resistance

Prediabetic State

Glucose Intolerance

Endometrial Neoplasms

Hyperinsulinism

Metabolic Diseases

Glucose Metabolism Disorders

Uterine Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Hypoglycemic Agents

All Drugs and Chemicals

Insulin

Insulin, Globin Zinc

Participants who have had endometrial cancer (cases).

Participants who have not had endometrial cancer (controls).

Questionnaire taking about 20 minutes to complete.

Questionnaire

Karen H. Lu, MD

The goal of this clinical research study is to find out if there is a link between insulin resistance (or pre-diabetes) and endometrial cancer.

Primary Objective:

1. To determine the association between insulin resistance and endometrial cancer in women in Harris County, Texas. 2. To assess the effect of body mass index (BMI) on the association between insulin resistance and endometrial cancer.

Secondary Objectives:

1. To explore the association between polycystic ovarian syndrome (PCOS) and endometrial cancer.
2. To assess the relationship between known reproductive risk factors, menstrual risk factors, family history and endometrial cancer.
3. To explore the molecular changes associated with insulin resistance and PCOS on normal endometrium and tumor tissue.

This study will be comparing women who have had endometrial cancer (cases) to women who have not had endometrial cancer (controls) in Harris County, Texas to better understand the risk factors for getting endometrial cancer. Insulin resistance is a condition of pre-diabetes. Polycystic ovarian syndrome (PCOS) is a condition associated with irregular periods, obesity, infertility, and/or difficulty in getting pregnant. Both insulin resistance and PCOS are believed to increase a woman's risk of getting endometrial cancer.

As part of this study, you will be asked to fill out a questionnaire that asks about your medical history, weight history, family history, reproductive history, and birth control/hormone use. The questionnaire should take about 20 minutes to complete, and you will need to complete it only once. You will have your height and weight measured, and about 4 teaspoons of blood will be drawn to test for insulin resistance (or pre-diabetes). You will be required to fast, not eat or drink anything except water, for 8 hours before having this blood sample drawn. If you are premenopausal and still have both your ovaries, you will have an additional 4 teaspoons of blood drawn to test for PCOS. You will complete the questionnaire during your first visit or at home and will bring it back with you when you come back for your fasting blood test appointment.

If you have been diagnosed with endometrial cancer and have had surgery to remove your uterus, you will also be asked to give permission to use a piece of your leftover tumor and surrounding normal tissue to test for markers of insulin resistance and PCOS. This will be from tissue that was removed during your surgery and will not require another biopsy or surgery.

You will not be required to come back for any follow-up as part of this study. However, you will be asked to fill out a form that asks if you would be willing to be called in the future to participate in other studies.

This is an investigational study. A total of 700 women will take part in this multicenter study, 350 women with endometrial cancer and 350 women without endometrial cancer. A total of up to 350 women will be enrolled at M.D. Anderson.

Blood sample and, if diagnosed with endometrial cancer and had surgical removal of uterus, a piece of leftover tumor and surrounding normal tissue will be tested for markers of insulin resistance and PCOS.

Study of Insulin Resistance and Endometrial Cancer in Harris County, Texas

Case-Control Study of Insulin Resistance and Endometrial Cancer in Harris County, Texas

M.D. Anderson Cancer Center

Carcinoma

Uterine Cervical Neoplasms

Carcinoma in Situ

Uterine Cervical Diseases

New cervical cancer patients through stage IVB presenting to the LBJ Gyn-Onc Clinic.

Series of surveys to be completed at the time of diagnosis and within one month after completion of treatment, taking approximately 45 minutes each time.

Lois M. Ramondetta, MD

The goal of this behavioral research study is to look at the reasons that may prevent women from getting early treatment for their cervical cancer.

Little is known about what prevents women with cervical cancer from getting early and possibly curative treatment. This study consists of a series of questionnaires that ask questions about religion; coping; access to health care; physical, emotional, and spiritual well-being; understanding of health questions; control; fear; anxiety; and other health beliefs to determine why some women delay coming in for check-ups and why some women do not complete their treatments. It is thought that health beliefs influence behavior practices and that by identifying these issues, things can be done to improve the health condition and results for these patients.

You will be asked to complete a series of questionnaires at 2 specific time points: The first time point will be before treatment begins and the second time point will be within a month following completion of treatment.

Filling out the questionnaires should take about 45 minutes each time. You should have adequate time to complete these questionnaires during your clinic appointment.

If you want to take part but are too ill to complete the questionnaires, you will be provided a pre-addressed, stamped envelope, so that you can mail them back to the study staff at your earliest convenience.

This is an investigational study. This is an investigational study. Up to 150 patients will be enrolled at Lyndon B. Johnson General Hospital.

A Prospective Study Examining the Barriers to Care for Harris County Cervical Cancer Patients

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Study of Insulin Resistance and Endometrial Cancer in Harris County, Texas	NCT00495235	Endometrial Can...	Questionnaire	-	M.D. Anderson Cancer Center
A Prospective Study Examining the Barriers to Care for Harris County Cervical Cancer Patients	NCT00519272	Cervical Cancer	Questionnaire	-	M.D. Anderson Cancer Center

Spots Global Cancer Trial Database for harris county