Digestive System Diseases

Diseases and Abnormalities at or Before Birth

All Conditions

Symptoms and General Pathology

Musculoskeletal Diseases

Nervous System Diseases

Rare Diseases

Hirschsprung Disease

Gastroparesis

Muscle Spasticity

Esophageal Diseases

Diverticulum

Diverticular Diseases

Zenker Diverticulum

Neurologic Manifestations

Stomach Diseases

Gastrointestinal Diseases

Paralysis

Congenital Abnormalities

Digestive System Abnormalities

Megacolon

Colonic Diseases

Intestinal Diseases

Gastroenteritis

Pathological Conditions, Anatomical

Diverticulum, Esophageal

To test the idea that submucosal endoscopy is effective and safe for endoscopic myotomy, endoscopic submucosal dissection, and access for tissue acquisition and resection. Submucosal endoscopy is a recent innovative addition to gastrointestinal endoscopy. This involves endoscopic maneuvers in the gut wall, by dissection of the submucosal layer of GI tract, thereby allowing endoscopic myotomy (incision of the muscle), endoscopic access for tissue acquisition and therapy, and resection of precancerous and cancerous gastrointestinal tissue. This approach has been a dramatic game-changer for minimally invasive management of various gastrointestinal conditions such as Zenker's diverticulum, Achalasia, Spastic Esophageal Disorders, Gastroparesis, esophageal obstruction, Hirschsprung's Disease, and Gastrointestinal neoplasia.

The aim of the proposed study is to prospectively assess technical success, clinical success, and adverse events after submucosal endoscopy. Technical success will be defined as ability to successfully complete the submucosal endoscopic procedure. Clinical success will be defined as symptom relief and objective evaluation which will be assessed with radiologic imaging, repeat endoscopy, gastrointestinal motility studies, and pathology results routinely performed post-procedure for clinical care, as indicated. Adverse events will be recorded per published ASGE criteria.

A database/ registry of patients undergoing submucosal endoscopic procedures will be created to demonstrate this.

Prospective Evaluation of the Efficacy and Safety of Submucosal Endoscopy

Improvement in symptoms and objectively assessed by radiologic imaging, repeat endoscopy, gastrointestinal motility studies, and pathology.

Submucosal endoscopy technique and device used

University of Colorado, Denver

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Prospective Evaluation of the Efficacy and Safety of Submucosal Endoscopy	NCT03626350	Gastrointestina... Hirschsprung's ... Esophageal Obst... Gastroparesis Spastic Esophag... Zenker's Divert...		18 Years - 89 Years	University of Colorado, Denver
Prospective Evaluation of the Efficacy and Safety of Submucosal Endoscopy	NCT03626350	Gastrointestina... Hirschsprung's ... Esophageal Obst... Gastroparesis Spastic Esophag... Zenker's Divert...		18 Years - 89 Years	University of Colorado, Denver

Spots Global Cancer Trial Database for hirschsprung's disease