Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Breast Neoplasms

Breast Diseases

Skin Diseases

Yiwei Tong

Xiaosong Chen

The goal of this clinical trial is to learn about the mutation spectrum of homologous recombination repair pathway genes and its instructive significance in the treatment of Chinese breast cancer patients.

The main questions it aims to answer are:

1. What is the mutation spectrum of homologous recombination repair pathway genes in Chinese breast cancer patients?
2. Does homologous recombination repair pathway gene mutation have an impact on patient outcome (breast cancer recurrence, neoadjuvant chemotherapy efficacy, treatment decisions, etc.) ? There is no intervention on participants, but all participants will be given regular follow-up post surgery according to ASCO guidelines.

Homologous Recombination Repair Pathway Gene Mutation Spectrum in Chinese Breast Cancer Patients

Homologous Recombination Repair Pathway Gene Mutation Spectrum in Chinese Breast Cancer Patients: A Multi-center, Prospective, Observational Study

to reveal the homologous recombination repair pathway gene mutation spectrum

to compare the incidence of breast cancer-related events and deaths between patients with or without homologous recombination repair pathway gene mutation(s)

to compare the treatment decision and appliance between patients with or without homologous recombination repair pathway gene mutation(s)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Homologous Recombination Repair Pathway Gene Mutation Spectrum in Chinese Breast Cancer Patients	NCT05901025	Breast Cancer		-	Shanghai Jiao Tong University School of Medicine
Homologous Recombination Repair Pathway Gene Mutation Spectrum in Chinese Breast Cancer Patients	NCT05901025	Breast Cancer		-	Shanghai Jiao Tong University School of Medicine

Spots Global Cancer Trial Database for homologous recombination repair pathway