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After completing the pre-test survey, participants from all intervention groups will receive the written information. Subsequently, they will be randomly assigned to one of the intervention groups. The K-Talk group will receive a series of weekly storytelling videos, and access to the chatbot via the web-based platform KakaoTalk for 3 months.

After completing the pre-test survey, participants from all intervention groups will receive the written information. Subsequently, they will be randomly assigned to one of the intervention groups. The storytelling intervention group will only be exposed to periodic release of stories via email for 3 months.

After completing the pre-test survey, participants from all intervention groups will receive the written information. Subsequently, they will be randomly assigned to one of the intervention groups. The K-Bot group will only interact with the chatbot via the web-based platform or KakaoTalk for 3 months.

This group will only be exposed to written, didactic HPV education materials after the pre-test.

The K-Talk intervention group receives a combination of a storytelling intervention and an artificial intelligence chatbot (K-Bot) education.

K-Talk Intervention (Storytelling and K-Bot)

The storytelling intervention features 12 authentic stories from young Korean immigrants and Americans. Each video is about 3 minutes long and includes stories from 1st, 1.5, and 2nd generation young Korean individuals, highlighting their perceptions of HPV and HPV vaccines, and their experiences with HPV vaccination.

Storytelling Intervention

The K-Bot intervention is a conversational and button-based artificial intelligence Chatbot that is available in both English and Korean.

K-Bot Intervention

The written information provided includes the Centers for Disease Control and Prevention's (CDC) details on HPV and HPV vaccines.

Written Information

Minjin Kim, PhD., RN

Minjin Kim

The goal of this clinical trial is to test the feasibility, acceptability, and preliminary efficacy of a storytelling video-based intervention using AI chatbot technology (K-Talk) to promote HPV vaccination behavior among Korean Americans aged 18 to 45.

The main questions this study aims to answer are:

* Is the K-Talk intervention feasible for use among Korean Americans aged 18 to 45?
* Is the K-Talk intervention acceptable to the target population?
* What is the preliminary efficacy of the K-Talk intervention in promoting HPV vaccination uptake?

Participants will be Korean Americans aged 18 to 45 who are at risk for HPV infection. Participants will be asked to complete a baseline survey and then will be "randomized" into one of four groups: Group 1 (chatbot + storytelling intervention), Group 2 (chatbot only), Group 3 (storytelling only), and Group 4 will be only exposed to written didactic HPV education materials. All groups will receive written didactic HPV education materials. Researchers will compare how Group 1, a combination of AI Chatbot and storytelling intervention is more effective than other intervention groups in promoting HPV vaccination uptake among underserved, hard-to-reach Korean Americans.

The objective of this study is to conduct a pilot Multiphase Optimization Strategy trial (MOST) to evaluate the acceptability, feasibility, and preliminary efficacy of K-Talk as an intervention to improve HPV vaccination initiation and completion among Korean American men and women. K-Talk is a user-centered intervention that combines AI chatbot technology with storytelling to enhance health communication, foster connection, and provide accurate advice related to HPV vaccination. The study design follows an optimization phase of the MOST, utilizing a 2 x 2 factorial design with two factors (storytelling and chatbot) and two levels (Yes/On and No/Off). The study aims to recruit a total of 160 participants, with 40 participants assigned to each experimental condition. The sample will consist of 80 males and 80 females who are eligible for participation in factorial experimentation using the MOST design. Interested individuals will undergo an online eligibility screening survey. If eligible for the study, participants will receive an online survey link containing informed consent, a baseline survey, written HPV information, and random assignment to an intervention group.

Participants will be randomized to one of four experimental conditions using a 2x2 factorial design with two factors (Storytelling and Chatbot) and two levels (Yes/On and No/Off). Acceptability and feasibility outcomes include recruitment/retention rates, obtaining photographic documentation, and perceived satisfaction with the intervention.

Qualtrics is an online survey software used by researchers. It can randomly assign participants to different groups without revealing the assignments to participants or researchers, blinding them to the assignment. This ensures unbiased treatment and assessment of participants.

Let's K-Talk - HPV Study for Ethnic Koreans

Let's K-Talk: A Storytelling Intervention Leveraging Chatbot Technology to Prevent HPV and HPV Associated Cancers for Ethnic Koreans Living in the U.S.

Sharing only aggregated data will be presented in a summary format without any identifying information about individual participants.

Participants who received at least one dose of HPV vaccine at 3-month

Participants who received at least one dose of HPV vaccine at 6-month

Participants who received at least one dose of HPV vaccine at 12-month

Higher scores represent better knowledge.

Higher scores indicate higher risk perceptions about HPV and STI

Two questions will be used to assess participants' intention to receive HPV vaccines: "Do you intend to get the HPV vaccine?" and "How likely is it that you will get an HPV vaccine in the next 3 months?"

University of Cincinnati

Assistant Professor

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Mouth and Tooth Diseases

Ear, Nose, and Throat Diseases

Rare Diseases

Uterine Cervical Neoplasms

Uterine Cervical Dysplasia

Oropharyngeal Neoplasms

Uterine Cervical Diseases

Uterine Diseases

Genital Diseases, Female

Genital Diseases

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Female Urogenital Diseases

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Female Urogenital Diseases and Pregnancy Complications

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Pharyngeal Diseases

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Cervical Intraepithelial Neoplasia

Women born in 1997, resident to Norway in 2009, vaccinated by the quadrivalent HPV vaccine.

Interventions:

* Self sample from vagina using Rover's Evalyn Brush
* Self sample from the oral cavity using COPAN's FloqSwab
* Questionnaire

Women born in 1997, resident to Norway in 2009, not vaccinated by the quadrivalent HPV vaccine

Interventions:

* Self sample from vagina using Rover's Evalyn Brush
* Self sample from the oral cavity using COPAN's FloqSwab
* Questionnaire

Self sample using The Rover's Evalyn Brush

Self sample from vagina

Self sample from the oral cavity

Questionnaire about vaccination status and sexual behaviour

Questionnaire

Espen Enerly, Dr Scient

Giske Ursin, Dr.Med

The overall aim of the study is to assess the effect of school-based Human Papillomavirus (HPV) vaccination by comparing type-specific HPV prevalence between vaccinated and non-vaccinated women born in 1997. Women born in 1997, residence to Norway in 2009 (the year of vaccine initiation of the 1997-cohort) are invited to participate in the study.

This cohort is amongst the first that was offered HPV vaccine in an organized vaccination programme globally. The women will be recruited through Facebook ads. The study will enable us to measure differences in the prevalence of HPV types in vagina and the mouth between vaccinated and non-vaccinated young women in Norway.

The womens vaccination status will be validated by linkage to the Norwegian Immunisation Registry (SYSVAK) and their residence status will be validated through linkage to the Norwegian Population Registry.

Self samples from vagina and the oral cavity

Impact of HPV Vaccine On The Prevalence Of HPV In Norway

Impact of HPV Vaccine On The Prevalence Of Human Papillomavirus In Mouth And Vagina In Norway

The differences in HPV types prevalence among vaccinees and non-vaccinees. HPV types will be assessed individually and combined.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Let's K-Talk - HPV Study for Ethnic Koreans	NCT05884697	Human Papilloma... Papillomavirus ...	K-Talk Interven... Storytelling In... K-Bot Intervent... Written Informa...	18 Years - 45 Years	University of Cincinnati
Impact of HPV Vaccine On The Prevalence Of HPV In Norway	NCT02934724	Cervical Intrae... Cervical Cancer Oropharyngeal C...	Self sample fro... Self sample fro... Questionnaire	18 Years - 20 Years	Oslo University Hospital
Impact of HPV Vaccine On The Prevalence Of HPV In Norway	NCT02934724	Cervical Intrae... Cervical Cancer Oropharyngeal C...	Self sample fro... Self sample fro... Questionnaire	18 Years - 20 Years	Oslo University Hospital

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