Neoplasms

Digestive System Diseases

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Colorectal Neoplasms

Aberrant Crypt Foci

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Cola

All identified ACF eliminated by cold or hot colonoscopic biopsy forceps

ACF quantified and observed, re-evaluated after one year

All ACF removed by either cold or hot colonoscopic biopsy forceps

Surgical removal of ACF

Stain-enhanced magnification endoscopy performed, ACF quantified at entry and after one year

Colonoscopic evaluation only

Peter W. Soballe, M.D.

We hypothesized that aberrant crypt foci (ACF) are precursors of colon cancer; their prevention would correlate with cancer risk and their elimination would reduce that risk. In this study we wished to (1) establish the feasibility of stain-enhanced magnification colonoscopy, (2) determine whether colorectal cancer is asociated with increased numbers of ACF, and (3) investigate the natural history of ACF and the durability of their elimination.

Subjects are randomly assigned at the time of stain-enhanced magnification colonoscopy to have any ACF removed or merely observed. Subjects are evenly divided into those with and those without a personal history of colon cancer. ACF are tabulated by an observer blinded to the subject's personal history. All subjects are then re-evaluated after one year by an observer blinded to the original procedure.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Colonoscopic Removal of Aberrant Crypt Foci: a Prospective, Randomized, Blinded Trial	NCT00623883	Colorectal Neop...	Surgical remova... Colonoscopic ev...	18 Years -	National Naval Medical Center
Colonoscopic Removal of Aberrant Crypt Foci: a Prospective, Randomized, Blinded Trial	NCT00623883	Colorectal Neop...	Surgical remova... Colonoscopic ev...	18 Years -	National Naval Medical Center

Spots Global Cancer Trial Database for human colonic aberrant crypt foci