Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Lung Neoplasms

Multiple Pulmonary Nodules

Solitary Pulmonary Nodule

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

A cohort of 1000 patients with incidental lung nodules will be identified using clinical records at participating NHS sites.

Link-anonymised CT scan images and data will be stored using a central database for radiomics and artificial intelligence research, to predict the risk of malignancy.

Patient's scans will be used as input into in-house software to extract multiple radiomics features. These features will be used to develop a risk-signature which can predict malignancy risk. Patient scans will also be used as input into deep learning/convolutional neural network models to perform automated imaging classification.

Machine Learning Classification

Richard Lee, MBBS PhD

Benjamin Hunter

Richard Lee

Dr Shafick Gareeboo

Shafick Gareeboo

Jonathon Ratoff

Dr Neal Navani

Neal Navani

Anand Deveraj

Dr Anand Deveral

This study will collect retrospective CT scan images and clinical data from participants with incidental lung nodules seen in hospitals across London. The investigators will research whether machine learning can be used to predict which participants will develop lung cancer, to improve early diagnosis.

Lung Nodule Imaging Biobank for Radiomics and AI Research

The primary endpoint will be met if we are able to store baseline CT scans and the minimum clinical data set for 1000 patients.

We aim to identify distinct clusters of radiomics variables to generate a radiomics predictive vector (RPV), which can be used to stratify patients according to malignancy risk. This vector will be used in multivariate analysis and compared to existing risk models.

RM Partners West London Cancer Alliance

Royal Brompton & Harefield NHS Foundation Trust

University College London Hospitals

Imperial College Healthcare NHS Trust

Lewisham and Greenwich NHS Trust

King's College Hospital NHS Trust

Epsom and St Helier University Hospitals NHS Trust

Institute of Cancer Research, United Kingdom

Guy's and St Thomas' NHS Foundation Trust

UCLH Biomedical Research Centre

Royal Marsden NHS Foundation Trust

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Lung Nodule Imaging Biobank for Radiomics and AI Research	NCT04270799	Lung Cancer Pulmonary Nodul... Pulmonary Nodul... Lung Neoplasms	Machine Learnin...	18 Years -	Royal Marsden NHS Foundation Trust
Lung Nodule Imaging Biobank for Radiomics and AI Research	NCT04270799	Lung Cancer Pulmonary Nodul... Pulmonary Nodul... Lung Neoplasms	Machine Learnin...	18 Years -	Royal Marsden NHS Foundation Trust

Spots Global Cancer Trial Database for incidental lung nodules