Neoplasms

Skin and Connective Tissue Diseases

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Breast Neoplasms

Breast Diseases

Skin Diseases

As inject only indocyanine green (ICG), it provide the surgeon visual guidance to ensure better outcome.

indocyanine green

So-Youn Jung

Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has been used for breast cancer surgery such as sentinel lymph node (SLN) mapping and breast cancer localization.

In this study, our hypothesis are as following:

1. As inject only indocyanine green (ICG), it provide the surgeon visual guidance to ensure better outcome.
2. indocyanine green (ICG) permitted accurate preoperative and intraoperative detection of the SLNs as well as nonpalpable benign brest lesion in patients with breast cancer.

Indocyanine green, ICG (ICG-fluorescence)

* ICG is the most commonly used fluorophore which approve by FDA.
* NIR-F imaging with ICG could be used in various surgeries. For example, SLN mapping in breast cancer and localization of liver metastasis, especially superficial lesion
* Contains sodium iodide, patients who have history of allergy to iodides should be used as caution.

Nonpalpable benign brest lesion localization

* New method for the localization and resection of non-palpable breast lesions.
* The breast lesion was correctly localized, and the area of ICG corresponded well to the site of the lesions.

Clinical Application of Near-infrared Fluorescence Guided Localization on Breast Surgery in Breast Cancer

Clinical Application of Near-infrared Fluorescence Guided Localization on Breast Surgery in Breast Cancer: Interventional Pilot Study for 5 Patients

tumor detection rate and reoperation rate of resection margin

after complete resection with intraoperative ultrasound confirmed the lesion

determine the pathological stability with biopsy results confirmed during surgery

National Cancer Center, Korea

Medical Doctor

Clinical Application of Near-infrared Fluorescence Guided Localization on Breast Surgery in Benign Breast Neoplasm.

Clinical Application of Near-infrared Fluorescence Guided Localization on Breast Surgery in Benign Breast Neoplasm ; Observational Pilot Study for 20 Patients.

number of patients with pigmented skin lesion, number of patients with complication, number of patients with breast lymphedema, number of patients with residual breast lesion using breast ultrsound

non-palpable lesion localization rate = number of patients complete excision of lesion / 20 enrolled patients

actual lesion of width\*height\*length / resection lesion of width\*height\*length

Medical Dotor

As inject only indocyanine green (ICG), it provide the surgeon visual guidance to ensure better outcome.

Intervention: Drug: indocyanine green

A Prospective Clinical Study for Evaluation of Safe Resection Margin in Breast Conserving Surgery in Breast Cancer

A Prospective Clinical Study for Evaluation of Safe Resection Margin in Breast Conserving Surgery

Itchiness, erythema, rash and other allergic reactions there could have shots later.

Itchiness, erythema, rash and other allergic reactions there could have shots later.

Itchiness, erythema, rash and other allergic reactions there could have shots later.

Itchiness, erythema, rash and other allergic reactions there could have shots later.

After scanning, difficulty breathing, a decrease in blood pressure checked whether he had o reaction, such as anaphylactic shock.

The skin discoloration, verify that there aren't stay in a follow-up after three months after surgery.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Clinical Application of Near-infrared Fluorescence Guided Localization on Breast Surgery in Breast Cancer	NCT02473159	Breast Cancer	indocyanine gre...	20 Years - 70 Years	National Cancer Center, Korea
Clinical Application of Near-infrared Fluorescence Guided Localization on Breast Surgery in Breast Cancer	NCT02473159	Breast Cancer	indocyanine gre...	20 Years - 70 Years	National Cancer Center, Korea
Clinical Application of Near-infrared Fluorescence Guided Localization on Breast Surgery in Benign Breast Neoplasm.	NCT02172989	Benign Breast N...		20 Years - 70 Years	National Cancer Center, Korea
Clinical Application of Near-infrared Fluorescence Guided Localization on Breast Surgery in Benign Breast Neoplasm.	NCT02172989	Benign Breast N...		20 Years - 70 Years	National Cancer Center, Korea
A Prospective Clinical Study for Evaluation of Safe Resection Margin in Breast Conserving Surgery in Breast Cancer	NCT02817334	Breast Cancer	indocyanine gre...	18 Years -	National Cancer Center, Korea

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