Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Endometrial Neoplasms

Uterine Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Lymphadenectomy recommended, including: obturator, iliac (internal, external, common) and aortic lymph nodes

Lymphadenectomy

Frederick Ueland, M.D.

Complete pelvic and para-aortic lymphadenectomy performed at the time of primary surgical staging for endometrial cancer increases operative time and surgical morbidity, but appears to be necessary in most high grade and deeply invasive cancers. To date, the Mayo Clinic approach has not been reproduced, and the investigators propose to validate their algorithm at the University of Kentucky utilizing intra-operative consultation (IOC). The preliminary data at the University of Kentucky for IOC and endometrial cancer outcomes suggest that the investigators are well-suited to perform this investigation. A surgical approach that is tailored to the patient's cancer biology is rational, supported by the recent literature, and medically compelling since the co-morbidities of many obese, low-risk EC patients put them at significantly increased perioperative risk for complete lymphadenectomy.

Selective Surgical Staging for the Treatment of Endometrial Cancer Based on Intraoperative Consultation

Surgical Staging for the Treatment of Endometrial Cancer Based on IOC

Recurrence-free survival rates in low-risk and high-risk subgroups of patients with endometrial cancer as classified by the use of pathology intraoperative consultation (IOC).

Progression-free survival rates in low-risk and high-risk subgroups of patients with endometrial cancer as classified by the use of pathology intraoperative consultation (IOC)

Disease-specific survival rates in low-risk and high-risk subgroups of patients with endometrial cancer as classified by the use of pathology intraoperative consultation (IOC)

Overall survival rates in low-risk and high-risk subgroups of patients with endometrial cancer as classified by the use of pathology intraoperative consultation (IOC)

Perioperative morbidity and mortality outcome will be assessed as the number of participants with Adverse Events/death which are related to treatment/surgery .

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Selective Surgical Staging for the Treatment of Endometrial Cancer Based on Intraoperative Consultation	NCT02658565	Endometrial Can...	Lymphadenectomy	18 Years - 100 Years	University of Kentucky
Intraoperative Pathological Evaluation for Surgical Treatment & Staging for Endometrial Cancer	NCT01512810	Endometrial Can...	Lymphadenectomy	18 Years -	University of Kentucky

Spots Global Cancer Trial Database for intraoperative consultation