Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Breast Neoplasms

Central Nervous System Depressants

All Drugs and Chemicals

Anesthetics

Once the patient is asleep under anesthetic, they receive an intraoperative injection of 1.0 mCi of Technetium-99 sulfur colloid into normal breast tissue surrounding the primary cancer or biopsy cavity directed subareolar or around the tumor. This is followed by blue dye injected in the subareolar complex approximately 5 minutes prior to incision. The sentinel node biopsy is performed, followed by lumpectomy/mastectomy, and a completion axillary node dissection if the sentinel node(s) were positive.

Sentinel Node Biopsy

V. Suzanne Klimberg, MD

We continue to collect information in support of the hypothesis that the histology of the first draining lymph node (sentinel node) accurately predicts the histology of the rest of the axillary lymph nodes.

Using a technique combining Technetium-99 sulfur colloid and Lymphazurin Blue Dye, we have established that the sentinel node predicts the pathology results of the rest of the axillary lymph nodes. This minimally invasive technique, which can be readily performed under local anesthesia, makes the need for full axillary lymph node dissection unnecessary for most patients. If the sentinel node is negative, no further surgery is necessary. If positive, a complete axillary node dissection is performed. In addition, the injections are made while the patient is under anesthesia, reducing the physical and psychological pain that accompanies injections done pre-operatively.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Sentinel Lymph Node Biopsy Using Peritumoral Injection With Blue Dye Confirmation	NCT00575744	Breast Cancer	Sentinel Node B...	18 Years -	University of Arkansas
Sentinel Lymph Node Biopsy Using Peritumoral Injection With Blue Dye Confirmation	NCT00575744	Breast Cancer	Sentinel Node B...	18 Years -	University of Arkansas

Spots Global Cancer Trial Database for intraoperative injection