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Ketamine

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Three 2.5-3 hour Ketamine Assisted Psychotherapy sessions, each 2-7 days apart

Ketamine, 0.5-1.2mg/kg, administered intramuscularly

* Doses can range 0.5-1.2 mg/kg. Starting dose for all participants will be 0.5mg/kg.
* Dose can be titrated up to maximum of 1.2 mg/kg or titrated down to 0.5 mg/kg based on response and clinical judgement.
* Dose will be administered by injecting into large muscle mass (eg, deltoid, gluteal muscle, thigh)

Susan Sharry

Benjamin Lewis, MD

The goal of this open-label clinical trial is to assess the feasibility of Ketamine-assisted psychotherapy (KAP) studies for adults with non-operable GI cancers suffering with existential distress. The main questions it aims to answer are:

* Is it feasible to conduct a KAP study with this population?
* What is the safety and tolerability of KAP in this population?
* How prevalent is existential distress in this population?

Participants will undergo KAP administered as standard of care at the HMHI Park City Ketamine-Assisted Psychotherapy Clinic and will complete health assessments over the course of the study, as well as during the therapy.

Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI Cancers

TREK: Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI Cancers

To assess the feasibility of completion of the study intervention by 12 participants.

To assess the safety and tolerability of ketamine-assisted therapy in the study population.

To determine the prevalence of existential distress in patients with non-operable GI cancers.

University of Utah

Spots Global Cancer Trial Database for ketamine assisted therapy