Symptoms and General Pathology

All Conditions

Digestive System Diseases

Syndrome

Low Anterior Resection Syndrome

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Postoperative Complications

LARS score questionnaire is filled by the patient after anterior resection for rectal cancer to study the quality of life

LARS score questionnaire

Reham Zakaria, PhD

Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome.

With advances in colorectal surgery, sparing sphincter surgeries are gaining popularity. But symptoms after surgery can affect the quality of life which has psychomotor effects. Low anterior resection syndrome score is a worldwide known questionnaire. Many countries have accredited validation and translation of this questionnaire, but to our knowledge; it is the first time in Egypt.

Incidence and Risk Factors of Low Anterior Resection Syndrome

Incidence, Risk Factors Of Low Anterior Resection Syndrome And Validation Of LARS Score Among Egyptian Patients

IPD will be shared with other researchers on demand by e- mailing the principle investigator

age of the patients in years was recorded from patient records

sex of patients was recorded from patient records

medical disease like diabetes and hypertension was recorded from patient records

tumor site was determined in Cm from anal verge by colonoscopy

history of neoadjuvant therapy before surgery was obtained from patients records

site of anastmosis after resection was recorded as colo-rectal or colo-anal

excision of meso-rectum was recorded if it was partial or complete

it was recorded from patients records if he\\she had chemo- or radiotherapy post-operatively

from records; surgery was open or laparoscopic

type of anastmosis(hand sewen or stappled) obtained from records

obtained by LARS questionnaire filled by the patient during follow up, it was formed of five questions with different scores on answer choices, interpretaion (0-20) means no LARS, (21- 29) means minor LARS, (30-42) means major LARS

Zagazig University

Principal Investigator

This group will be instructed on High-volume TAI to be perform daily or every 2 days for 2 months. After 15 days of wash-out they will switch to Low-TAI treatment for 2 months.

This group will be instructed on Low-volume TAI to be perform daily or every 2 days for 2 months. After 15 days of wash-out they will switch to the Low-TAI treatment for 2 months.

The High-TAI (400-1000ml) will be self-performed using the Peristeen® Transanal irrigation system with the conic catheter every 48 hours during the first two week of treatment. Then patients could change frequency and volume of TAI depending on their needs and/or preference.

The Low-TAI will be self-performed using a standard 250ml water enema every 48 hours during the first two week of treatment. Then patients could change frequency of TAI depending on their needs and/or preference.

Peristeen® Transanal irrigation system with the conic catheter

Standard reusable enema

Loris Trenti, PhD

Alba Aramburu

Loris Trenti, MD

The aim of this study is to investigate whether the high-volume transanal irrigation (TAI) performed by the Peristeen Plus® system is superior to the low-volume TAI performed by standard 250ml water enema for the treatment of Low Anterior Resection Syndrome (LARS).

Most of the patients operated on for rectal cancer present defecatory disfunction symptoms known as Low Anterior Resection Syndrome (LARS) of different degree and severity. Although, transanal irrigation (TAI) has been shown to be useful in improve LARS and quality of life of these patients no evidence exists about the best way to realize TAI in terms of irrigation volume and systems and frequency of irrigation. This crossover randomized controlled trial aims to evaluate the impact of two different type of TAI (high-volume by Peristeen Plus® and low-volume performed by 250ml water enema) on LARS and quality of life in patients with major LARS secondary to low anterior rectal resection (LAR) for primary rectal cancer. The primary outcome is the reduction of LARS score after two months of treatment.

Transanal Irrigation for Low Anterior Resection Syndrome.

High-volume and Low-volume Water Transanal Irrigation for the Management of Low Anterior Resection Syndrome. A Crossover Randomized Controlled Clinical Trial.

LARS score changes with treatments.

No LARS: 0-20; Minor LARS 21-29; Major LARS 30-42.

Quality of life changes with treatments.

Values between 0-100 (higher score means better outcome).

Fecal incontinence symptoms change with treatments.

Values between 0-24 (higher score means worse outcome).

Patients' satisfaction grade related with treatments

What treatment is preferred by the patients after having tried both

Adverse effects and complication directly related with one of the two treatments.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Incidence and Risk Factors of Low Anterior Resection Syndrome	NCT06359730	Colorectal Canc...	LARS score ques...	18 Years - 60 Years	Zagazig University
Transanal Irrigation for Low Anterior Resection Syndrome.	NCT05245331	Low Anterior Re...	Peristeen® Tran... Standard reusab...	18 Years -	Hospital Universitari de Bellvitge

Spots Global Cancer Trial Database for lars

Every month we try and update this database with for lars cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for lars

Every month we try and update this database with for lars cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for lars cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.