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Liver Extracts

Norihisa Yada, M.D.

Kazuomi Ueshima, M.D.

Masatoshi Kudo, Professor

This is a multi-center cohort study in which the Real-time Tissue Elastography® measurements will predict prospectively the incidence of hepatocellular carcinoma, the incidence and severity of gastroesophageal varices ascites and decompensated cirrhosis in hepatitis B or C patients.

The aim of this study is to validate the predictive value of Real-time Tissue Elastography® by comparison with serum marker or FibroScan® in chronic hepatitis B or C patients.

Every year and for three years, we performed Real-time Tissue Elastography®, blood sampling, gastrointestinal endoscopy. If in the hospital they can perform FibroScan®, FobroScan® also be performed.

Subjects were also performed ultrasonography (US), computed sonography (CT) or magnetic resonance imaging (MRI) evry four or six months.

The time between the Real-time Tissue Elastography®, blood sampling, gastrointestinal endoscopy and FiroScan® must not exceed four weeks.

Prediction of Incidence of Liver Cancer by Use of Real-time Tissue Elastography

Prediction of Incidence of Liver Cancer or PorTal Hypertension in Patients With Viral Hepatitis by Use of Real-time Tissue Elastography

Cumulative incidence of carcinogenesis of hepatocellular carcinoma defined as the time from registration to diagnosis of hepatoceluler carcinomais

Cancer-free survival is defined as the time from registration to death due to cencer or any cause

Overall survival is defined as the time from registration to death due to any cause

It is estimated by gastrointestinal scope for every year

Jaundice, ascites, edema and hepatic encephalopathy etc. is evaluated as decompensated cirrhosis.

Kindai University

Japan Liver Oncology Group Organization:

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Prediction of Incidence of Liver Cancer by Use of Real-time Tissue Elastography	NCT01360892	Chronic Hepatit... Chronic Hepatit...		20 Years -	Kindai University
Prediction of Incidence of Liver Cancer by Use of Real-time Tissue Elastography	NCT01360892	Chronic Hepatit... Chronic Hepatit...		20 Years -	Kindai University

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