Heart and Blood Diseases

All Conditions

Digestive System Diseases

Infections

Symptoms and General Pathology

Neoplasms

Rare Diseases

Hypertension

Hypertension, Portal

Hepatitis A

Hepatitis C

Hepatitis

Fibrosis

Hepatitis B

Hepatitis B, Chronic

Liver Neoplasms

Hepatitis, Chronic

Virus Diseases

Hepatitis C, Chronic

Liver Diseases

Gastrointestinal Diseases

Hepatitis, Viral, Human

Communicable Diseases

Enterovirus Infections

Picornaviridae Infections

RNA Virus Infections

Blood-Borne Infections

Flaviviridae Infections

Hepadnaviridae Infections

DNA Virus Infections

Chronic Disease

Disease Attributes

Gastrointestinal Neoplasms

Digestive System Neoplasms

Chronic Graft Versus Host Disease

Herpes Simiae (B Virus)

Hematinics

All Drugs and Chemicals

Liver Extracts

Norihisa Yada, M.D.

Kazuomi Ueshima, M.D.

Masatoshi Kudo, Professor

This is a multi-center cohort study in which the Real-time Tissue Elastography® measurements will predict prospectively the incidence of hepatocellular carcinoma, the incidence and severity of gastroesophageal varices ascites and decompensated cirrhosis in hepatitis B or C patients.

The aim of this study is to validate the predictive value of Real-time Tissue Elastography® by comparison with serum marker or FibroScan® in chronic hepatitis B or C patients.

Every year and for three years, we performed Real-time Tissue Elastography®, blood sampling, gastrointestinal endoscopy. If in the hospital they can perform FibroScan®, FobroScan® also be performed.

Subjects were also performed ultrasonography (US), computed sonography (CT) or magnetic resonance imaging (MRI) evry four or six months.

The time between the Real-time Tissue Elastography®, blood sampling, gastrointestinal endoscopy and FiroScan® must not exceed four weeks.

Prediction of Incidence of Liver Cancer by Use of Real-time Tissue Elastography

Prediction of Incidence of Liver Cancer or PorTal Hypertension in Patients With Viral Hepatitis by Use of Real-time Tissue Elastography

Cumulative incidence of carcinogenesis of hepatocellular carcinoma defined as the time from registration to diagnosis of hepatoceluler carcinomais

Cancer-free survival is defined as the time from registration to death due to cencer or any cause

Overall survival is defined as the time from registration to death due to any cause

It is estimated by gastrointestinal scope for every year

Jaundice, ascites, edema and hepatic encephalopathy etc. is evaluated as decompensated cirrhosis.

Kindai University

Japan Liver Oncology Group Organization:

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Immune System Diseases

Carcinoma

Liver Cirrhosis

Carcinoma, Hepatocellular

Acquired Immunodeficiency Syndrome

HIV Infections

Coinfection

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Adenocarcinoma

Nicolás Merchante, MD PhD

Prospective multicenter cohort recruiting consecutive patients from 7 hospitals in Andalusia, southern Spain, according to following criteria: 1) HIV infection, 2) Chronic active HCV infection, 3) Older than 18 years, 4) New diagnosis of liver cirrhosis on the basis of a liver stiffness above 14 kiloPascals, 5) No previous or concomitant decompensation of liver disease. Patients are prospectively followed-up according to a uniform protocol of care. Epidemiological, clinical and laboratory variables are periodically recorded. The primary outcomes are the emergence of a liver decompensation (including hepatocellular carcinoma), liver transplant or death. The predictors of these outcomes are analyzed.

Serum samples are collected and immediately frozen for criopreservation

Natural History of Liver Cirrhosis Diagnosed by Transient Elastography in HIV/HCV-coinfected Patients

Episodes of liver decompensation will include those episodes of ascites, spontaneous bacterial peritonitis, portal hypertensive gastrointestinal bleeding, hepatorrenal syndrome, hepatic encephalopathy, hepatocellular carcinoma, non obstructive jaundice and acute on chronic liver failure. These episodes will be diagnosed according to standard definitions of clinical practice guidelines in the field (i.e. HCC diagnosis will be diagnosed according to AASLD criteria, spontaneous bacterial peritonitis and hepatorenal syndrome will be diagnosed following the EASL criteria, portal hypertensive gastrointestinal bleeding according Baveno VI consensus definition,...)

Study title	NCT ID	Conditions	Eligibility	Organization
Prediction of Incidence of Liver Cancer by Use of Real-time Tissue Elastography	NCT01360892	Chronic Hepatit... Chronic Hepatit...	20 Years -	Kindai University
Natural History of Liver Cirrhosis Diagnosed by Transient Elastography in HIV/HCV-coinfected Patients	NCT02693847	Liver Cirrhosis Hepatocellular ... HIV HCV Coinfection	18 Years -	Hospital Universitario de Valme
Prediction of Incidence of Liver Cancer by Use of Real-time Tissue Elastography	NCT01360892	Chronic Hepatit... Chronic Hepatit...	20 Years -	Kindai University

Spots Global Cancer Trial Database for liver stiffness