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Treatment of cervical neoplasia by thermal ablation

Women screened for cervical cancer by visual inspection with diluted acetic acid (VIA) presenting lesions eligible for ablative treatment were treated by thermal ablation. The treatment consisted in applying the probe on the lesion for 45 seconds at 100 degrees Celsius, with one to up to five applications depending on the lesion size. Following treatment, women were inquired about the pain level during the procedure, their satisfaction level of the procedure and whether they would recommend this treatment to their relatives. Women had a follow-up visit at 6 weeks to assess any complication of the procedure. Women were rescreened at 12 months, to evaluate the cure rate and any long-term adverse events.

Sylvestre Bazikamwe, MD

Catherine Sauvaget, MD, PhD

Longitudinal study in Burundi to evaluate the effectiveness, the acceptability and safety of thermal ablation in the treatment of cervical neoplasia.

The study population consisted of women with an abnormal VIA test or an abnormal colposcopy examination. A total of 86 women with lesions eligible to ablative treatment were counselled and treated by thermal ablation. Informed consent was signed by each participant. Just after treatment, they were inquired about the level of pain during the procedure, and their level of satisfaction with the treatment. They were followed-up at 6 weeks for any complication and re-assessed by VIA and colposcopy at 12 months for any persistent or recurrent lesion and for any adverse event.

Evaluating Thermal Ablation in the Treatment of Cervical Neoplasia

Effectiveness is measured by the cure rate after 1 year based on VIA and colposcopy assessment.

Measured by existence of minor/moderate adverse events during the follow-up.

Measured by the satisfaction level using a nine-level Likert scale (from 1. Very unsatisfied to 9. very satisfied).

Measured by existence of severe adverse events during the follow-up period.

Kamenge University Hospital, Burundi University, Burundi

International Agency for Research on Cancer

Patients receiving standard oncologic care plus palliative care.

Patients receiving standard oncologic care.

The Palliative Care Package is a protocol for Palliative Care delivery, derived from the African Palliative Care Association and adapted to the local environment in Addis Ababa.

Palliative care

Standard Oncological Care available in Addis Ababa, Ethiopia which includes chemotherapy, radiation oncology

Standard oncological care

Eleanor Reid, MD

To understand the impact of initiation of palliative care in this low-resource setting, and whether palliative care is a cost-reducing intervention that will improve patient-reported outcomes and quality of life.

The investigators overall goal is to understand the impact of initiation of early palliative care in an oncology population in a low-resource setting in order to provide guidance for future public health policies surrounding the provision of palliative care in Ethiopia. Hypothesis: The investigators hypothesize that initiation of palliative care in this low-resource setting is a cost-reducing intervention that will improve patient-reported outcomes and quality of life. Preliminary data: This research will focus on adult patients with oncologic diagnoses as preliminary research in this setting revealed that this patient population had the highest depression and anxiety scores, the lowest palliative outcome scores, and reported the highest costs of medical care.

A randomized controlled trial of standard oncologic care versus standard oncologic care plus palliative care in a newly diagnosed oncology population.

Examining Early Palliative Care in Newly Diagnosed Cancer Patients

A Study of Early Palliative Care in Newly Diagnosed Cancer Patients at Black Lion Hospital, Addis Ababa, Ethiopia

Evaluating the direct costs of all medical care,

Evaluating the direct costs of all medical care.

APCA POS: APCA POS measures unpleasant symptoms (pain, worry, other symptoms) on a scale of 0-5 (best to worst). We will measure at baseline.

APCA POS: APCA POS measures unpleasant symptoms (pain, worry, other symptoms) on a scale of 0-5 (best to worst). We will compare baseline score to follow up score. An APCA POS score decrease of 3 from baseline will be signficant.

HADS score measures anxiety and depression on a scale of 0-3 (best to worst). We will measure at baseline.

HADS score measures anxiety and depression on a scale of 0-3 (best to worst). HADS score decrease from baseline, as measured at follow up.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Evaluating Thermal Ablation in the Treatment of Cervical Neoplasia	NCT05211271	Cervical Neopla...	Treatment of ce...	-	International Agency for Research on Cancer
Examining Early Palliative Care in Newly Diagnosed Cancer Patients	NCT03712436	Cancer	Palliative care Standard oncolo...	18 Years -	Yale University
Examining Early Palliative Care in Newly Diagnosed Cancer Patients	NCT03712436	Cancer	Palliative care Standard oncolo...	18 Years -	Yale University

Spots Global Cancer Trial Database for lmic

Every month we try and update this database with for lmic cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for lmic

Every month we try and update this database with for lmic cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for lmic cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.