Symptoms and General Pathology

All Conditions

Neoplasms

Behaviors and Mental Disorders

Rare Diseases

Pain

Pain, Procedural

Neuroblastoma

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Neuroepithelial

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Neoplasms, Glandular and Epithelial

Neoplasms, Nerve Tissue

Quality of Life

Oculocerebral Syndrome With Hypopigmentation

Neuroepithelioma

Analgesics

All Drugs and Chemicals

Central Nervous System Depressants

Ropivacaine

Propofol

Hypnotics and Sedatives

Anesthetics

Anesthetics, Intravenous

Anesthetics, General

Anesthetics, Local

1st Bone Marrow procedure (BM) Intervention A: propofol first. Then second BM procedure with propofol \& ropivacaine

1st BM procedure: Intervention B: propofol \& ropivacaine first. Then second BM procedure with propofol

propofol

ropivacaine

Nurses will record patient-reported pain scores.

Wong-Baker FACES® Pain Rating Scale

Post-procedural quality of life (QOL)

Ellen Basu, MD, PhD

The purpose of this study is to identify whether or not the addition of a numbing medicine that is injected directly into the site of the bone marrow procedure can reduce pain and the use of opioid pain medication after bone marrow procedures. The addition of this medicine, called ropivacaine, is the experimental part of this study. This is the first time ropivacaine will be directly injected into the bone marrow site at MSKCC Pediatrics.

Local Injection of Pain Medication to Reduce Pain After Bone Marrow Procedures in Pediatric Neuroblastoma Patients

RePPAIR -Reducing Procedural Pain and Improving Recovery of Quality of Life in Pediatric Neuroblastoma Patients Undergoing Bone Marrow Procedures: A Prospective Randomized Cross-over Clinical Trial

Number of participants requiring post-procedural opioid analgesia within 24 hours (+/- 4 hours) post procedure per study arm

Memorial Sloan Kettering Cancer Center

Participants received propofol \& ropivacaine in combination

Propofol and Ropivacaine

ARM 1: 1st Bone Marrow procedure (BM) Intervention A: propofol first. Then second BM procedure with propofol \& ropivacaine

Propofol With Placebo First Then Propofol With Ropivacaine

ARM 2: 1st BM procedure: Intervention B: propofol \& ropivacaine first. Then second BM procedure with propofol

Propofol With Ropivacaine First Then Propofol With Placebo

Total

Age, Continuous

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

United States

United Kingdom

Region of Enrollment

Dr. Ellen Basu, MD, PhD

Require postprocedural opioid

Did not Require postprocedural opioid

Propofol Alone

Participants who received propofol \& ropivacaine

Propofol & Ropivacaine

Number of Participants Requiring Post-procedural Opioid Analgesia Per Study Arm

Overall Study

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Local Injection of Pain Medication to Reduce Pain After Bone Marrow Procedures in Pediatric Neuroblastoma Patients	NCT02924324	Neuroblastoma	propofol ropivacaine Wong-Baker FACE... Post-procedural...	3 Years - 18 Years	Memorial Sloan Kettering Cancer Center
Local Injection of Pain Medication to Reduce Pain After Bone Marrow Procedures in Pediatric Neuroblastoma Patients	NCT02924324	Neuroblastoma	propofol ropivacaine Wong-Baker FACE... Post-procedural...	3 Years - 18 Years	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for local injection