Symptoms and General Pathology

All Conditions

Neoplasms

Skin and Connective Tissue Diseases

Recurrence

Breast Neoplasms

Disease Attributes

Diana Gonçalves, MD, PhDc

Janete Santos, PhD

José Luis Fougo, MD, PhD

The ReLoCC project is a prospective, multicenter, clinical study to register cases of local recurrence after breast-conserving surgery, in centers dedicated to the treatment of breast cancer, in Portugal and Spain.

The comparison of the results obtained will allow the optimization of the treatment, making it increasingly personalized.

Registry of Local Recurrences After Breast-conserving Surgery

Registry of Local Recurrences After Breast-conserving Surgery in Portugal and Spain

Validated questionnaire for quality of life by EORTC QLQ-C30-BR23

Centro Hospitalar Universitário São João, EPE

Universidade do Porto

Breast Diseases

Skin Diseases

Interstitial PDR- and HDR-brachytherapy up to 50 Gy-eq

Interstitial multicatheter brachytherapy

Vratislav Strnad, MD, Prof.

Godehard Lahmer, MD

Accelerated partial breast irradiation (APBI) leads to a equivalent local control rate with lower toxicity as external beam irradiation (EBI) after breast conserving surgery (BCS) in a highly selected subgroup of patients with low risk invasive carcinoma and low risk duct carcinoma in-situ (DCIS). The goal of this trial is to assess the role of a modified dose of pulsed-dose-rate (PDR) and high-dose-rate (HDR) brachytherapy alone as Accelerated Partial Breast Irradiation (APBI) in a defined low-risk group of invasive breast cancer or ductal carcinoma in situ concerning local failure (all ipsilateral local recurrences), in particular regarding the local recurrences, the toxicity and for the cosmetic result. It is a phase II study. According to study protocol altogether 200 female patients will be treated.

Focus of this trial is to assess the role a modified dose of PDR- and HDR-brachytherapy as Accelerated Partial Breast Irradiation (APBI) alone in a defined low-risk group of invasive breast cancer or ductal carcinoma in situ concerning local failure(all ipsilateral local recurrences, in particular regarding the local recurrences, the toxicity and for the cosmetic result.

Dose Optimization for Pulsed-dose-rate (PDR)/High-dose-rate (HDR) Brachytherapy Alone for Early Breast Cancer

Phase II Study - Dose Optimization PDR/HDR Brachytherapy Alone for Early Breast Cancer

to assess the incidence and severity of acute and late side effects of brachytherapy

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Registry of Local Recurrences After Breast-conserving Surgery	NCT05406661	Breast Cancer R...		18 Years -	Universidade do Porto
Registry of Local Recurrences After Breast-conserving Surgery	NCT05406661	Breast Cancer R...		18 Years -	Universidade do Porto
Dose Optimization for Pulsed-dose-rate (PDR)/High-dose-rate (HDR) Brachytherapy Alone for Early Breast Cancer	NCT01175694	Breast Cancer	Interstitial mu...	50 Years -	University Hospital Erlangen

Spots Global Cancer Trial Database for local recurrences