Neoplasms

All Conditions

Adenocarcinoma

Carcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

All Drugs and Chemicals

Anti-Infective Agents

Antineoplastic Agents

Poly ICLC

Interferons

Immunologic Factors

Dendritic cell and Poly-ICLC vaccination will be administered directly into the tumor on Day 0 and Day 14 of Treatment Phase. Subjects will then have standard of care procedures along with injections of Poly-ICLC and dendritic cells for the remainder of the study.

Poly-ICLC

dendritic cell

The main purpose of this study is to examine the safety of the study drug in patients with locally advanced unresectable pancreatic adenocarcinoma. The study team would like to know about any side effects a patient may have when given the study drug. Another goal of the study is to determine if combining dendritic cells and the study drug can be possibly used as a vaccine for this disease. Dendritic cells are cells that are present in the body's immune system that help your body fight disease.

A Study of Vaccination With Poly-ICLC and Dendritic Cells in Patients With Pancreatic Adenocarcinoma

A Feasibility and Safety Study of Vaccination With Poly-ICLC and Dendritic Cells in Patients With Locally Advanced Unresectable Pancreatic Adenocarcinoma

Number of Participants With Adverse Events (AEs)

Evaluate the frequency of toxicities by type and severity, and dose of study drug according to the Common Toxicity Criteria for Adverse Events (CTCAE) version 4.0.

Determining the feasibility of generating dendritic cells and administering these cells as a vaccine to patients

Number of Participants With Tumor Response

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Study of Vaccination With Poly-ICLC and Dendritic Cells in Patients With Pancreatic Adenocarcinoma	NCT01677962	Pancreatic Aden...	Poly-ICLC dendritic cell	18 Years -	Medical University of South Carolina
A Study of Vaccination With Poly-ICLC and Dendritic Cells in Patients With Pancreatic Adenocarcinoma	NCT01677962	Pancreatic Aden...	Poly-ICLC dendritic cell	18 Years -	Medical University of South Carolina

Spots Global Cancer Trial Database for locally advanced, unresectable pancreatic adenocarcinoma