Neoplasms

Symptoms and General Pathology

All Conditions

Neoplasm Metastasis

Neoplastic Processes

Treatment Arm 1: Single-fraction spine SRS (22 Gy x 1)

Single-fraction spine SRS

Treatment Arm 2: Multi-fraction spine SRS (14 Gy x 2)

Multi-fraction spine SRS

Aniket Pratapneni

Jillian Skerchak

Erqi L Pollom, M.D.

The goal of this study is to determine whether fractionated Stereotactic radiosurgery (SRS) for spine metastases is associated with improved local tumor control compared to single-fraction SRS. Patients will be randomized to treatment with spine SRS using either 22 Gy in 1 fraction or 28 Gy in 2 fractions.

Comparing SingLe- Vs Multi-Fraction Spine STereotActic Radiosurgery in Spinal Metastases

A Randomized Phase III TriaL Comparing SingLe- Versus Multi-Fraction Spine STereotActic Radiosurgery for Patients With Spinal Metastases (ALL-STAR)

To determine whether fractionated Stereotactic Radiosurgery (SRS) for spine metastases is associated with improved local tumor control at 1 year following SRS compared to single-fraction SRS.

To compare health-related quality of life (EQ-5D-3L) following SRS and assess patient-reported health related quality of life pertaining to mobility, self-care, usual activities, pain, and anxiety.

To compare health-related quality of life (EORTC QLQ-C30) following SRS and assess patient-reported health related quality of life pertaining to overall health and quality of daily life.

To compare health-related quality of life (EORTC QLQ-BM22) following SRS and assess patient-reported health related quality of life pertaining to pain associated with performing activities of daily life.

Pain associated with the treated area will be assessed by asking patients to rate their pain on a 0-10 scale ("no pain" to "pain as bad as you can imagine")

Collect medications taken within the last 24 hours.

To determine 1-year rate CTCAE grade 2 or higher adverse effects, following SRS

To determine 1-year rate of vertebral compression fracture (VCF), following SRS

To determine 2-year rate of local failure following SRS

Stanford University

Wounds and Injuries

Rupture

Cysts

Pathological Conditions, Anatomical

Central Nervous System Depressants

All Drugs and Chemicals

Anti-Inflammatory Agents

Respiratory System Agents

Bupivacaine

Betamethasone

Betamethasone Valerate

Betamethasone-17,21-dipropionate

Betamethasone benzoate

Betamethasone sodium phosphate

Betamethasone acetate phosphate

Patients will be treated by introducing a 20G spinal needle in the inferior joint recess of the zygapophyseal joint.1 ml of celestone-chronodose,1 ml of Marcain 5 mg/ml and 1-3 ml of contrast media:Omnipaque 240 will be injected until the cyst ruptures.

Percutaneous zygapophyseal cyst rupture

Øivind Gjertsen, Md, Msc

Lumbar zygapophyseal joint cysts can cause lower extremity radiculopathy. These cysts can be cured by a minimally invasive technique: percutaneous cyst distention and rupture

Lumbar zygapophyseal joint cysts can cause lower extremity radiculopathy. These cysts can be cured by a minimally invasive technique: percutaneous cyst distention and rupture.

30 patient with lower extremity radiculopathy caused by lumbar zygapophyseal joint cysts will be included in the study.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Comparing SingLe- Vs Multi-Fraction Spine STereotActic Radiosurgery in Spinal Metastases	NCT06173401	Spinal Metastas...	Single-fraction... Multi-fraction ...	18 Years -	Stanford University
Comparing SingLe- Vs Multi-Fraction Spine STereotActic Radiosurgery in Spinal Metastases	NCT06173401	Spinal Metastas...	Single-fraction... Multi-fraction ...	18 Years -	Stanford University
Percutaneous Rupture of Zygapophyseal Joint Cysts	NCT00837070	Zygapophyseal S...	Percutaneous zy...	20 Years -	Oslo University Hospital
Comparing SingLe- Vs Multi-Fraction Spine STereotActic Radiosurgery in Spinal Metastases	NCT06173401	Spinal Metastas...	Single-fraction... Multi-fraction ...	18 Years -	Stanford University

Spots Global Cancer Trial Database for lumbar

Every month we try and update this database with for lumbar cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for lumbar

Every month we try and update this database with for lumbar cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for lumbar cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.